Playoff Series Breakdown
| First Round Playoff: Cubs @ Pirates | ||
| 1 | Pirates 5, Cubs 1 | WP: Adams LP: Arrieta |
| 2 | Cubs 7, Pirates 3 | WP: Imanaga LP: Skenes |
| 3 | Cubs 6, Pirates 3 | WP: Hendricks LP: DeLeon |
| Cubs Win Series 2-1 | ||
| First Round Playoff: Giants @ Reds | ||
| 1 | Reds 2, Giants 1 | WP: LeCure LP: Hearn |
| 2 | Reds 7, Giants 6 | WP: Eller LP: Strickland |
| Reds Win Series 2-0 | ||
| First Round Playoff: Mariners @ Yankees | ||
| 1 | Yankees 5, Mariners 1 | WP: Cortes Jr. LP: Gilbert |
| 2 | Yankees 4, Mariners 3 | WP: Weaver LP: Soriano |
| Yankees Win Series 2-0 | ||
| First Round Playoff: Rangers @ Twins | ||
| 1 | Twins 3, Rangers 2 | WP: Johnson LP: Eovaldi |
| 2 | Rangers 6, Twins 3 | WP: deGrom LP: Nathan |
| 3 | Rangers 7, Twins 6 | WP: Feliz LP: Neshek |
| Rangers Win Series 2-1 | ||
| Second Round Playoff: Rangers @ Red Sox | ||
| 1 | Rangers 2, Red Sox 0 | WP: Eovaldi LP: Steele |
| 2 | Rangers 5, Red Sox 3 | WP: deGrom LP: Shore |
| 3 | Red Sox 8, Rangers 6 | WP: Wood LP: Ryan |
| 4 | Red Sox 8, Rangers 0 | WP: Sale LP: Darvish |
| 5 | Rangers 8, Red Sox 3 | WP: Eovaldi LP: Steele |
| Rangers Win Series 3-2 | ||
| Second Round Playoff: Reds @ Rockies | ||
| 1 | Rockies 3, Reds 0 | WP: Jimenez LP: Greene |
| 2 | Rockies 8, Reds 7 | WP: Ottavino LP: Hall |
| 3 | Reds 4, Rockies 3 | WP: Seaver LP: Marquez |
| 4 | Reds 7, Rockies 6 | WP: Dibble LP: Miller |
| 5 | Rockies 5, Reds 4 | WP: Jimenez LP: Greene |
| Rockies Win Series 3-2 | ||
| Second Round Playoff: Cubs @ Mets | ||
| 1 | Mets 7, Cubs 2 | WP: Fernandez LP: Arrieta |
| 2 | Mets 4, Cubs 3 | WP: Scherzer LP: Imanaga |
| 3 | Cubs 5, Mets 2 | WP: Hendricks LP: Harvey |
| 4 | Mets 8, Cubs 5 | WP: Martinez LP: Eckersley |
| Mets Win Series 3-1 | ||
| Second Round Playoff: Yankees @ Astros | ||
| 1 | Astros 2, Yankees 1 | WP: Cole LP: Cortes Jr. |
| 2 | Astros 8, Yankees 2 | WP: Javier LP: Cole |
| 3 | Yankees 9, Astros 3 | WP: Guidry LP: Richard |
| 4 | Astros 8, Yankees 1 | WP: Scott LP: Severino |
| Astros Win Series 3-1 | ||
| Third Round Playoff: Rockies @ Mets | ||
| 1 | Mets 2, Rockies 1 | WP: deGrom LP: Ottavino |
| 2 | Rockies 8, Mets 1 | WP: Betancourt LP: Scherzer |
| 3 | Mets 5, Rockies 2 | WP: Harvey LP: Jimenez |
| 4 | Rockies 6, Mets 1 | WP: Betancourt LP: Martinez |
| 5 | Rockies 5, Mets 3 | WP: Logan LP: Carlyle |
| 6 | Mets 2, Rockies 1 | WP: Scherzer LP: Marquez |
| 7 | Rockies 3, Mets 2 | WP: Jimenez LP: Harvey |
| Rockies Win Series 4-3 | ||
| Third Round Playoff: Rangers @ Astros | ||
| 1 | Astros 6, Rangers 0 | WP: Cole LP: deGrom |
| 2 | Astros 7, Rangers 1 | WP: Javier LP: Ryan |
| 3 | Rangers 5, Astros 4 | WP: Uehara LP: Blubaugh |
| 4 | Astros 6, Rangers 5 | WP: Scott LP: Darvish |
| 5 | Astros 8, Rangers 7 | WP: Urquidy LP: Smith |
| Astros Win Series 4-1 | ||
| World Series: Rockies @ Astros | ||
| 1 | Astros 16, Rockies 4 | WP: Cole LP: Gray |
| 2 | Astros 5, Rockies 2 | WP: Verlander LP: Marquez |
| 3 | Astros @ Rockies | |
| 4 | Astros @ Rockies | |
| 5 | Astros @ Rockies | |
| 6 | Rockies @ Astros | |
| 7 | Rockies @ Astros | |
| Astros Lead Series 2-0 | ||
