Playoff Series Breakdown
| First Round Playoff: Indians @ Angels | ||
| 1 | Angels 6, Indians 1 | WP: Shields LP: Erlin |
| Angels Win Series 1-0 | ||
| First Round Playoff: Mets @ Nationals | ||
| 1 | Nationals 1, Mets 0 | WP: Matsuzaka LP: Thornburg |
| Nationals Win Series 1-0 | ||
| Second Round Playoff: Dodgers @ Cardinals | ||
| 1 | Cardinals 4, Dodgers 2 | WP: Liriano LP: Kershaw |
| 2 | Cardinals 8, Dodgers 7 | WP: Peacock LP: Downs |
| 3 | Cardinals 3, Dodgers 2 | WP: Miller LP: Delgado |
| Cardinals Win Series 3-0 | ||
| Second Round Playoff: Angels @ Red Sox | ||
| 1 | Red Sox 7, Angels 1 | WP: Fernandez LP: Feldman |
| 2 | Angels 3, Red Sox 2 | WP: Wright LP: Webb |
| 3 | Red Sox 4, Angels 2 | WP: Zimmermann LP: Shields |
| 4 | Red Sox 9, Angels 4 | WP: Nova LP: Holland |
| Red Sox Win Series 3-1 | ||
| Second Round Playoff: Royals @ Athletics | ||
| 1 | Royals 3, Athletics 2 | WP: Buchholz LP: Hernandez |
| 2 | Royals 9, Athletics 8 | WP: Benoit LP: Stammen |
| 3 | Athletics 4, Royals 2 | WP: Buehrle LP: Parra |
| 4 | Athletics 3, Royals 0 | WP: Chen LP: Bailey |
| 5 | Royals 6, Athletics 4 | WP: Buchholz LP: Hernandez |
| Royals Win Series 3-2 | ||
| Second Round Playoff: Nationals @ Phillies | ||
| 1 | Nationals 3, Phillies 0 | WP: Wainwright LP: Iwakuma |
| 2 | Phillies 6, Nationals 5 | WP: Machi LP: Workman |
| 3 | Nationals 8, Phillies 5 | WP: Matsuzaka LP: Ohlendorf |
| 4 | Nationals 8, Phillies 0 | WP: Corbin LP: Arroyo |
| Nationals Win Series 3-1 | ||
| Third Round Playoff: Nationals @ Cardinals | ||
| 1 | Cardinals 3, Nationals 1 | WP: Liriano LP: Wainwright |
| 2 | Cardinals 5, Nationals 0 | WP: Gray LP: Hamels |
| 3 | Cardinals 3, Nationals 2 | WP: Miller LP: Matsuzaka |
| 4 | Nationals 10, Cardinals 0 | WP: Corbin LP: Redmond |
| 5 | Nationals 2, Cardinals 1 | WP: Santos LP: Smith |
| 6 | Cardinals 4, Nationals 2 | WP: Gray LP: Hamels |
| Cardinals Win Series 4-2 | ||
| Third Round Playoff: Royals @ Red Sox | ||
| 1 | Royals 1, Red Sox 0 | WP: Roark LP: Cecil |
| 2 | Red Sox 3, Royals 0 | WP: Minor LP: Wacha |
| 3 | Royals 3, Red Sox 2 | WP: Ayala LP: Crain |
| 4 | Royals 7, Red Sox 2 | WP: Bailey LP: Nova |
| 5 | Red Sox 2, Royals 1 | WP: Fernandez LP: Maholm |
| 6 | Red Sox 2, Royals 1 | WP: Minor LP: Wacha |
| 7 | Red Sox 7, Royals 4 | WP: Zimmermann LP: Buchholz |
| Red Sox Win Series 4-3 | ||
| World Series: Cardinals @ Red Sox | ||
| 1 | Red Sox 2, Cardinals 1 | WP: Fernandez LP: De La Rosa |
| 2 | Red Sox 4, Cardinals 1 | WP: Nova LP: Miller |
| 3 | Cardinals 2, Red Sox 1 | WP: Smith LP: Crain |
| 4 | Cardinals 7, Red Sox 6 | WP: Smith LP: Zimmermann |
| 5 | Red Sox 4, Cardinals 3 | WP: Cecil LP: Liriano |
| 6 | Cardinals 2, Red Sox 0 | WP: Miller LP: Nova |
| 7 | Red Sox 5, Cardinals 0 | WP: Minor LP: Gray |
| Red Sox Win Series 4-3 | ||
