| SP | Carrasco, C.Carrasco, Carlos † | Indians | R | 129.0 | 25 | 25 | 15 | 6 | 2.59 | .248 | 0.97 | 6.8 | 1.9 | 10.0 | 173.2 | 131 | 51 | 50 | 18 | 37 | 192 | 3 | 0 | 0 | 1 | 19 | 4 | 5 | 2.84 |
| RP | Bradley, A.Bradley, Archie † | Angels | R | 108.0 | 74 | 0 | 7 | 1 | 1.95 | .247 | 0.94 | 6.1 | 2.5 | 10.0 | 101.2 | 68 | 24 | 22 | 6 | 28 | 112 | 0 | 14 | 3 | 0 | 0 | 4 | 0 | 2.50 |
| SP | Paxton, J.Paxton, James † | White Sox | L | 104.0 | 25 | 25 | 13 | 11 | 2.82 | .273 | 1.11 | 7.3 | 2.7 | 10.7 | 172.1 | 140 | 61 | 54 | 13 | 51 | 205 | 2 | 0 | 0 | 1 | 20 | 3 | 12 | 2.54 |
| RP | Doolittle, S.Doolittle, Sean † | Angels | L | 103.0 | 78 | 0 | 12 | 2 | 2.14 | .236 | 0.92 | 5.4 | 2.9 | 10.2 | 92.2 | 55 | 22 | 22 | 5 | 30 | 104 | 0 | 4 | 0 | 0 | 0 | 1 | 4 | 2.46 |
| SP | Castillo, L.Castillo, Luis † | Mariners | R | 101.0 | 24 | 24 | 11 | 4 | 2.77 | .274 | 1.11 | 6.6 | 3.4 | 10.5 | 159.0 | 116 | 54 | 49 | 12 | 60 | 185 | 0 | 0 | 0 | 0 | 15 | 4 | 2 | 2.86 |
| SP | Rodriguez, E.Rodriguez, Eduardo † # | Rangers | L | 96.0 | 24 | 24 | 13 | 5 | 3.24 | .286 | 1.18 | 7.6 | 3.0 | 10.9 | 139.0 | 118 | 55 | 50 | 11 | 46 | 169 | 0 | 0 | 0 | 0 | 12 | 3 | 2 | 2.65 |
| SP | deGrom, J.deGrom, Jacob † | White Sox | R | 92.0 | 24 | 24 | 12 | 6 | 3.41 | .310 | 1.30 | 8.2 | 3.5 | 11.3 | 161.0 | 146 | 66 | 61 | 12 | 63 | 203 | 0 | 0 | 0 | 0 | 17 | 8 | 8 | 2.77 |