| SP | Carrasco, C.Carrasco, Carlos † | Indians | R | 132.0 | 24 | 24 | 15 | 5 | 2.44 | .246 | 0.95 | 6.7 | 1.9 | 10.0 | 170.0 | 127 | 47 | 46 | 17 | 35 | 188 | 3 | 0 | 0 | 1 | 19 | 4 | 4 | 2.78 |
| SP | Paxton, J.Paxton, James † | White Sox | L | 110.0 | 24 | 24 | 13 | 10 | 2.49 | .267 | 1.07 | 7.0 | 2.7 | 10.8 | 169.2 | 132 | 54 | 47 | 11 | 50 | 203 | 2 | 0 | 0 | 1 | 20 | 3 | 12 | 2.38 |
| RP | Bradley, A.Bradley, Archie † | Angels | R | 102.5 | 70 | 0 | 7 | 1 | 2.06 | .252 | 0.98 | 6.2 | 2.6 | 10.2 | 96.0 | 66 | 24 | 22 | 6 | 28 | 109 | 0 | 13 | 3 | 0 | 0 | 3 | 0 | 2.51 |
| SP | Castillo, L.Castillo, Luis † | Mariners | R | 102.0 | 23 | 23 | 11 | 3 | 2.61 | .270 | 1.09 | 6.5 | 3.3 | 10.6 | 151.2 | 109 | 49 | 44 | 11 | 56 | 178 | 0 | 0 | 0 | 0 | 15 | 3 | 2 | 2.76 |
| SP | deGrom, J.deGrom, Jacob † | White Sox | R | 100.0 | 23 | 23 | 12 | 5 | 3.04 | .302 | 1.25 | 7.9 | 3.3 | 11.5 | 157.0 | 138 | 58 | 53 | 9 | 58 | 201 | 0 | 0 | 0 | 0 | 17 | 8 | 8 | 2.45 |
| RP | Doolittle, S.Doolittle, Sean † | Angels | L | 99.0 | 74 | 0 | 11 | 1 | 2.05 | .230 | 0.89 | 5.2 | 2.8 | 10.1 | 88.0 | 51 | 20 | 20 | 5 | 27 | 99 | 0 | 4 | 0 | 0 | 0 | 1 | 4 | 2.44 |
| SP | Rodriguez, E.Rodriguez, Eduardo † # | Rangers | L | 95.0 | 23 | 23 | 13 | 5 | 3.16 | .283 | 1.16 | 7.5 | 3.0 | 10.9 | 134.0 | 111 | 51 | 47 | 10 | 45 | 162 | 0 | 0 | 0 | 0 | 12 | 3 | 2 | 2.63 |