Playoff Series Breakdown
| First Round Playoff: Athletics @ White Sox | ||
| 1 | Athletics 3, White Sox 2 | WP: Gaudin LP: Howry |
| Athletics Win Series 1-0 | ||
| First Round Playoff: Brewers @ Astros | ||
| 1 | Astros 2, Brewers 0 | WP: Oswalt LP: Woodard |
| Astros Win Series 1-0 | ||
| Second Round Playoff: Indians @ Red Sox | ||
| 1 | Indians 5, Red Sox 4 | WP: Wright LP: D'Amico |
| 2 | Red Sox 15, Indians 0 | WP: Duckworth LP: Lee |
| 3 | Indians 7, Red Sox 3 | WP: Sabathia LP: Ohka |
| 4 | Indians 7, Red Sox 4 | WP: Avery LP: Zambrano |
| Indians Win Series 3-1 | ||
| Second Round Playoff: Nationals @ Diamondbacks | ||
| 1 | Nationals 3, Diamondbacks 1 | WP: Armas LP: Webb |
| 2 | Diamondbacks 7, Nationals 5 | WP: Saunders LP: Vazquez |
| 3 | Nationals 8, Diamondbacks 1 | WP: Pavano LP: Stephens |
| 4 | Nationals 10, Diamondbacks 4 | WP: Vargas LP: DuBose |
| Nationals Win Series 3-1 | ||
| Second Round Playoff: Athletics @ Mariners | ||
| 1 | Mariners 2, Athletics 0 | WP: Cloude LP: Zito |
| 2 | Mariners 13, Athletics 1 | WP: Pineiro LP: Nomo |
| 3 | Athletics 5, Mariners 4 | WP: Calero LP: Soriano |
| 4 | Mariners 11, Athletics 1 | WP: Meche LP: Blanton |
| Mariners Win Series 3-1 | ||
| Second Round Playoff: Astros @ Pirates | ||
| 1 | Pirates 10, Astros 3 | WP: Wood LP: Miller |
| 2 | Pirates 6, Astros 0 | WP: Hernandez LP: Hampton |
| 3 | Astros 6, Pirates 1 | WP: Oswalt LP: Millwood |
| 4 | Astros 4, Pirates 3 | WP: Elarton LP: Gonzalez |
| 5 | Pirates 9, Astros 2 | WP: Wood LP: Miller |
| Pirates Win Series 3-2 | ||
| Third Round Playoff: Indians @ Mariners | ||
| 1 | Indians 7, Mariners 5 | WP: Baez LP: Mateo |
| 2 | Mariners 3, Indians 2 | WP: Mateo LP: Tavarez |
| 3 | Indians 13, Mariners 11 | WP: Sabathia LP: Johnson |
| 4 | Indians 4, Mariners 2 | WP: Avery LP: Meche |
| 5 | Mariners 4, Indians 3 | WP: Soriano LP: Tavarez |
| 6 | Mariners 9, Indians 8 | WP: Mateo LP: Tavarez |
| 7 | Indians 4, Mariners 3 | WP: Baez LP: Hernandez |
| Indians Win Series 4-3 | ||
| Third Round Playoff: Nationals @ Pirates | ||
| 1 | Pirates 7, Nationals 2 | WP: Hernandez LP: Armas |
| 2 | Pirates 8, Nationals 4 | WP: Millwood LP: Vazquez |
| 3 | Pirates 3, Nationals 1 | WP: Wood LP: Pavano |
| 4 | Pirates 6, Nationals 0 | WP: Williams LP: Vargas |
| Pirates Win Series 4-0 | ||
| World Series: Indians @ Pirates | ||
| 1 | Pirates 3, Indians 0 | WP: Wood LP: Wright |
| 2 | Pirates 6, Indians 5 | WP: Heredia LP: Riske |
| 3 | Pirates 6, Indians 5 | WP: Gonzalez LP: Tavarez |
| 4 | Pirates 10, Indians 3 | WP: Williams LP: Avery |
| Pirates Win Series 4-0 | ||
