| SP | Pineiro, J.Pineiro, Joel † | Mariners | R | 154.0 | 33 | 33 | 21 | 3 | 2.90 | .266 | 1.05 | 7.3 | 2.2 | 6.4 | 189.0 | 153 | 62 | 61 | 13 | 46 | 134 | 0 | 0 | 0 | 0 | 14 | 6 | 3 | 3.30 |
| RP | Soriano, R.Soriano, Rafael † | Mariners | R | 153.5 | 86 | 0 | 10 | 1 | 1.70 | .216 | 0.82 | 5.2 | 2.2 | 8.9 | 138.0 | 79 | 32 | 26 | 8 | 34 | 136 | 0 | 19 | 3 | 0 | 0 | 1 | 0 | 2.54 |
| SP | Santana, J.Santana, Johan † | Twins | L | 148.0 | 33 | 33 | 19 | 7 | 3.52 | .262 | 1.04 | 7.1 | 2.3 | 8.6 | 240.2 | 190 | 101 | 94 | 29 | 61 | 229 | 7 | 0 | 0 | 2 | 18 | 5 | 4 | 3.49 |
| CL | Walker, K.Walker, Kevin † | Blue Jays | L | 142.5 | 57 | 0 | 7 | 4 | 2.63 | .257 | 1.02 | 6.2 | 3.0 | 8.9 | 68.1 | 47 | 20 | 20 | 9 | 23 | 67 | 0 | 39 | 4 | 0 | 0 | 1 | 1 | 3.81 |
| SP | Duckworth, B.Duckworth, Brandon | Red Sox | R | 142.0 | 32 | 32 | 17 | 8 | 3.07 | .254 | 1.01 | 6.8 | 2.3 | 6.4 | 228.1 | 172 | 83 | 78 | 23 | 58 | 163 | 9 | 0 | 0 | 3 | 23 | 3 | 5 | 3.68 |
| SP | Halladay, R.Halladay, Roy | Blue Jays | R | 136.0 | 33 | 33 | 17 | 8 | 3.40 | .275 | 1.13 | 7.9 | 2.3 | 7.5 | 243.1 | 212 | 93 | 92 | 28 | 62 | 203 | 6 | 0 | 0 | 2 | 18 | 3 | 4 | 3.63 |
| SP | Sabathia, C.Sabathia, CC † | Indians | L | 133.0 | 31 | 31 | 17 | 2 | 3.44 | .277 | 1.13 | 6.6 | 3.5 | 7.9 | 206.2 | 152 | 85 | 79 | 21 | 81 | 181 | 2 | 0 | 0 | 0 | 21 | 5 | 3 | 3.82 |