| SP | McNally, D.McNally, Dave | 26 | Hou Astros | L | 98 | 39 | 39 | 19 | 11 | 2.99 | .247 | 0.97 | 6.4 | 2.3 | 4.6 | 318.2 | 226 | 109 | 106 | 23 | 82 | 162 | 17 | 0 | 0 | 3 | 26 | 6 | 4 | 3.75 |
| SP | Martinez, P.Martinez, Pedro | 29 | Cle Spiders | R | 100 | 39 | 39 | 19 | 17 | 3.63 | .267 | 1.07 | 7.9 | 1.7 | 7.7 | 295.1 | 260 | 125 | 119 | 36 | 57 | 254 | 11 | 0 | 0 | 2 | 25 | 6 | 6 | 3.51 |
| SP | Walsh, E.Walsh, Ed | 27 | Cle Spiders | R | 91 | 40 | 40 | 21 | 13 | 3.63 | .269 | 1.08 | 7.9 | 1.8 | 5.0 | 294.2 | 259 | 133 | 119 | 36 | 59 | 164 | 9 | 0 | 0 | 1 | 22 | 8 | 3 | 4.16 |
| SP | Tiant, L.Tiant, Luis | 28 | Balt Orioles | R | 99 | 36 | 36 | 19 | 12 | 3.15 | .268 | 1.08 | 6.4 | 3.4 | 7.8 | 294.1 | 208 | 115 | 103 | 41 | 110 | 255 | 13 | 0 | 0 | 0 | 26 | 6 | 4 | 4.26 |
| SP | Ford, R.Ford, Russ | 27 | Hou Astros | R | 95 | 36 | 36 | 18 | 14 | 3.43 | .268 | 1.07 | 7.4 | 2.3 | 4.4 | 289.0 | 237 | 117 | 110 | 23 | 73 | 140 | 19 | 0 | 0 | 3 | 18 | 8 | 6 | 3.91 |
| SP | Alexander, P.Alexander, Pete | 28 | NY Mets | R | 96 | 36 | 36 | 14 | 16 | 3.22 | .277 | 1.13 | 7.8 | 2.3 | 4.9 | 279.2 | 243 | 117 | 100 | 26 | 72 | 152 | 12 | 0 | 0 | 1 | 25 | 6 | 5 | 3.96 |
| SP | Sweeney, C.Sweeney, Charlie | 21 | Phi Quakers | R | 94 | 35 | 35 | 15 | 10 | 3.76 | .283 | 1.15 | 7.9 | 2.5 | 4.9 | 273.0 | 239 | 123 | 114 | 32 | 75 | 150 | 16 | 0 | 0 | 3 | 18 | 9 | 7 | 4.35 |
| SP | Hunter, C.Hunter, Catfish | 26 | Hou Astros | R | 92 | 33 | 33 | 17 | 14 | 3.01 | .270 | 1.10 | 7.5 | 2.4 | 4.1 | 269.0 | 224 | 102 | 90 | 20 | 71 | 124 | 20 | 0 | 0 | 2 | 24 | 4 | 7 | 3.88 |
| SP | Johnson, W.Johnson, Walter | 26 | STL Browns | R | 97 | 34 | 34 | 15 | 11 | 3.42 | .275 | 1.12 | 8.2 | 1.8 | 5.0 | 258.0 | 236 | 102 | 98 | 24 | 52 | 143 | 6 | 0 | 0 | 2 | 21 | 6 | 2 | 3.78 |
| SP | Kershaw, C.Kershaw, Clayton | 27 | Phi Quakers | L | 96 | 36 | 36 | 14 | 12 | 3.67 | .279 | 1.14 | 7.9 | 2.5 | 8.2 | 257.2 | 225 | 114 | 105 | 26 | 70 | 235 | 9 | 0 | 0 | 2 | 22 | 4 | 6 | 3.35 |
| SP | Gibson, B.Gibson, Bob | 33 | Pit Alleghenys | R | 99 | 34 | 34 | 9 | 17 | 3.92 | .312 | 1.34 | 8.7 | 3.4 | 5.5 | 257.1 | 248 | 132 | 112 | 26 | 96 | 157 | 7 | 0 | 0 | 0 | 19 | 6 | 4 | 4.28 |
| SP | Verlander, J.Verlander, Justin | 36 | NY Mets | R | 100 | 36 | 36 | 13 | 12 | 3.18 | .264 | 1.05 | 7.4 | 2.1 | 8.4 | 254.1 | 208 | 94 | 90 | 25 | 59 | 238 | 2 | 0 | 0 | 1 | 20 | 6 | 2 | 3.17 |
| SP | Koufax, S.Koufax, Sandy | 30 | Pit Pirates | L | 100 | 37 | 37 | 14 | 14 | 3.44 | .279 | 1.14 | 7.3 | 3.0 | 8.5 | 253.2 | 205 | 107 | 97 | 23 | 85 | 239 | 7 | 0 | 0 | 0 | 26 | 4 | 11 | 3.35 |
| SP | Mathewson, C.Mathewson, Christy | 28 | STL Browns | R | 94 | 35 | 35 | 10 | 19 | 4.48 | .300 | 1.26 | 9.1 | 2.2 | 5.3 | 251.1 | 254 | 144 | 125 | 33 | 62 | 149 | 6 | 0 | 0 | 0 | 18 | 7 | 6 | 4.35 |
| SP | King, S.King, Silver | 20 | Balt Orioles | R | 88 | 34 | 34 | 16 | 14 | 3.94 | .288 | 1.17 | 8.4 | 2.2 | 5.0 | 251.0 | 234 | 122 | 110 | 29 | 60 | 140 | 12 | 0 | 0 | 0 | 17 | 10 | 0 | 4.22 |
| SP | Kluber, C.Kluber, Corey | 31 | Balt Orioles | R | 99 | 35 | 35 | 17 | 12 | 4.03 | .287 | 1.17 | 8.0 | 2.5 | 8.4 | 250.1 | 223 | 124 | 112 | 26 | 70 | 234 | 4 | 0 | 0 | 0 | 18 | 10 | 4 | 3.44 |
| SP | Arrieta, J.Arrieta, Jake | 29 | Wash Senators | R | 98 | 34 | 34 | 13 | 12 | 3.02 | .262 | 1.06 | 7.0 | 2.5 | 7.6 | 241.2 | 187 | 91 | 81 | 21 | 68 | 204 | 8 | 0 | 0 | 2 | 24 | 3 | 5 | 3.32 |
| SP | deGrom, J.deGrom, Jacob | 30 | NY Mets | R | 96 | 33 | 33 | 14 | 14 | 3.60 | .280 | 1.16 | 7.8 | 2.6 | 8.0 | 240.1 | 208 | 104 | 96 | 22 | 70 | 214 | 2 | 0 | 0 | 1 | 19 | 3 | 3 | 3.32 |
| SP | Santana, J.Santana, Johan | 25 | Bos Red Sox | L | 95 | 35 | 35 | 17 | 9 | 3.29 | .278 | 1.15 | 8.2 | 2.1 | 8.3 | 238.1 | 217 | 96 | 87 | 19 | 56 | 220 | 3 | 0 | 0 | 2 | 22 | 2 | 3 | 2.92 |
| SP | Baldwin, L.Baldwin, Lady | 27 | Bos Red Sox | L | 84 | 37 | 37 | 12 | 17 | 4.63 | .306 | 1.31 | 8.8 | 3.0 | 4.6 | 237.1 | 233 | 139 | 122 | 30 | 79 | 121 | 5 | 0 | 0 | 0 | 19 | 2 | 6 | 4.65 |
| SP | Scherzer, M.Scherzer, Max | 34 | Pit Alleghenys | R | 97 | 32 | 32 | 17 | 11 | 2.90 | .253 | 1.00 | 7.0 | 2.0 | 8.4 | 235.2 | 183 | 82 | 76 | 18 | 52 | 219 | 5 | 0 | 0 | 1 | 22 | 4 | 2 | 2.85 |
| SP | Seaver, T.Seaver, Tom # | 27 | STL Browns | R | 89 | 32 | 32 | 12 | 17 | 4.91 | .324 | 1.42 | 9.8 | 3.0 | 7.8 | 234.2 | 254 | 139 | 128 | 34 | 79 | 204 | 5 | 0 | 0 | 0 | 14 | 4 | 4 | 4.21 |
| SP | McLain, D.McLain, Denny | 24 | Hou Astros | R | 93 | 31 | 31 | 13 | 14 | 3.85 | .276 | 1.13 | 7.6 | 2.5 | 5.4 | 231.1 | 196 | 100 | 99 | 34 | 65 | 138 | 15 | 0 | 0 | 4 | 15 | 3 | 2 | 4.60 |
| SP | Joss, A.Joss, Addie | 28 | Phi Quakers | R | 91 | 29 | 29 | 11 | 12 | 3.53 | .262 | 1.05 | 7.8 | 1.7 | 4.4 | 229.1 | 198 | 92 | 90 | 26 | 42 | 111 | 13 | 0 | 0 | 1 | 18 | 4 | 2 | 4.11 |
| SP | Brown, M.Brown, Mordecai | 33 | Cle Spiders | R | 89 | 31 | 31 | 14 | 11 | 3.34 | .283 | 1.17 | 7.6 | 2.9 | 4.2 | 223.2 | 188 | 94 | 83 | 20 | 73 | 105 | 3 | 0 | 0 | 0 | 21 | 4 | 4 | 4.26 |
| SP | Cole, G.Cole, Gerrit | 28 | Pit Alleghenys | R | 98 | 33 | 33 | 13 | 11 | 3.91 | .298 | 1.25 | 8.8 | 2.5 | 8.3 | 221.0 | 215 | 106 | 96 | 16 | 62 | 204 | 2 | 0 | 0 | 1 | 17 | 5 | 3 | 3.00 |
| SP | Scott, M.Scott, Mike | 31 | Lou Colonels | R | 95 | 33 | 33 | 11 | 18 | 3.92 | .278 | 1.14 | 7.7 | 2.5 | 8.1 | 220.2 | 189 | 109 | 96 | 27 | 62 | 199 | 6 | 0 | 0 | 1 | 19 | 4 | 7 | 3.69 |
| SP | Gooden, D.Gooden, Dwight | 21 | Det Tigers | R | 88 | 28 | 28 | 11 | 11 | 4.40 | .309 | 1.31 | 8.8 | 3.1 | 5.9 | 200.2 | 195 | 106 | 98 | 28 | 68 | 132 | 6 | 0 | 0 | 2 | 12 | 6 | 6 | 4.61 |
| SP | Hernandez, F.Hernandez, Felix | 28 | Balt Orioles | R | 93 | 29 | 29 | 12 | 9 | 3.72 | .287 | 1.19 | 8.1 | 2.6 | 7.9 | 198.1 | 179 | 91 | 82 | 26 | 58 | 173 | 5 | 0 | 0 | 3 | 19 | 2 | 8 | 3.87 |
| SP | Koonce, C.Koonce, Cal | 22 | Det Tigers | R | 22 | 35 | 35 | 9 | 11 | 4.23 | .325 | 1.44 | 9.2 | 3.8 | 3.8 | 195.2 | 199 | 114 | 92 | 24 | 83 | 82 | 0 | 0 | 0 | 0 | 13 | 0 | 5 | 5.04 |
| SP | Blue, V.Blue, Vida # | 22 | Wash Senators | L | 91 | 29 | 29 | 11 | 14 | 4.19 | .312 | 1.32 | 8.4 | 3.5 | 5.5 | 195.1 | 182 | 99 | 91 | 25 | 75 | 119 | 10 | 0 | 0 | 0 | 17 | 9 | 6 | 4.74 |
| SP | Marichal, J.Marichal, Juan | 29 | Lou Colonels | R | 92 | 27 | 26 | 11 | 9 | 4.34 | .288 | 1.17 | 8.6 | 2.0 | 5.0 | 184.2 | 175 | 102 | 89 | 27 | 41 | 102 | 4 | 0 | 0 | 2 | 12 | 8 | 1 | 4.60 |
| SP | Welch, M.Welch, Mickey | 30 | Lou Colonels | R | 38 | 30 | 27 | 6 | 17 | 5.36 | .335 | 1.49 | 9.5 | 3.8 | 3.9 | 183.0 | 194 | 119 | 109 | 30 | 78 | 79 | 3 | 1 | 0 | 0 | 11 | 5 | 7 | 5.63 |
| SP | Carlton, S.Carlton, Steve | 28 | Wash Senators | L | 84 | 26 | 25 | 9 | 11 | 3.71 | .297 | 1.25 | 8.4 | 2.8 | 5.2 | 177.0 | 165 | 80 | 73 | 22 | 56 | 103 | 6 | 0 | 0 | 0 | 15 | 3 | 4 | 4.45 |
| SP | Cicotte, E.Cicotte, Eddie | 33 | Cle Spiders | R | 88 | 25 | 25 | 13 | 9 | 3.43 | .302 | 1.27 | 8.2 | 3.3 | 4.2 | 176.0 | 160 | 72 | 67 | 11 | 64 | 82 | 4 | 0 | 0 | 1 | 17 | 4 | 2 | 4.04 |
| SP | Newhouser, H.Newhouser, Hal | 25 | Pit Pirates | L | 73 | 22 | 22 | 15 | 4 | 2.13 | .277 | 1.13 | 6.8 | 3.4 | 6.4 | 168.2 | 127 | 49 | 40 | 14 | 64 | 119 | 6 | 0 | 0 | 1 | 19 | 3 | 3 | 3.86 |
| SP | McGinnity, J.McGinnity, Joe # | 28 | Lou Colonels | R | 37 | 31 | 25 | 5 | 17 | 5.85 | .357 | 1.64 | 11.6 | 3.2 | 3.2 | 164.2 | 212 | 131 | 107 | 22 | 58 | 59 | 1 | 1 | 0 | 0 | 9 | 4 | 2 | 5.16 |
| SP | Coombs, J.Coombs, Jack | 28 | Pit Pirates | R | 80 | 26 | 26 | 11 | 11 | 3.79 | .302 | 1.28 | 7.8 | 3.7 | 5.3 | 164.0 | 142 | 87 | 69 | 16 | 68 | 97 | 3 | 0 | 0 | 0 | 15 | 3 | 4 | 4.38 |
| SP | Chesbro, J.Chesbro, Jack | 30 | Phi Quakers | R | 86 | 23 | 23 | 10 | 6 | 4.40 | .317 | 1.37 | 9.5 | 2.9 | 3.9 | 163.2 | 172 | 90 | 80 | 17 | 52 | 70 | 6 | 0 | 0 | 1 | 13 | 4 | 6 | 4.53 |
| SP | Clemens, R.Clemens, Roger # | 35 | Pit Alleghenys | R | 77 | 22 | 22 | 9 | 12 | 5.10 | .324 | 1.42 | 9.9 | 2.9 | 8.5 | 162.1 | 178 | 97 | 92 | 14 | 53 | 153 | 5 | 0 | 0 | 1 | 10 | 2 | 2 | 3.25 |
| SP | Richard, J.Richard, J.R. # | 29 | STL Browns | R | 70 | 22 | 22 | 11 | 8 | 4.62 | .312 | 1.35 | 8.6 | 3.6 | 6.8 | 161.2 | 153 | 87 | 83 | 21 | 65 | 122 | 7 | 0 | 0 | 0 | 12 | 2 | 9 | 4.43 |
| SP | Waddell, R.Waddell, Rube | 28 | Det Tigers | L | 71 | 23 | 22 | 9 | 13 | 3.95 | .294 | 1.24 | 8.5 | 2.7 | 5.2 | 152.2 | 144 | 80 | 67 | 25 | 45 | 87 | 9 | 0 | 0 | 0 | 12 | 2 | 7 | 4.92 |