| SP | Scherzer, M.Scherzer, Max | Pit Alleghenys | R | 141.0 | 32 | 32 | 17 | 11 | 2.90 | .253 | 1.00 | 7.0 | 2.0 | 8.4 | 235.2 | 183 | 82 | 76 | 18 | 52 | 219 | 5 | 0 | 0 | 1 | 22 | 4 | 2 | 2.85 |
| SP | Martinez, P.Martinez, Pedro | Cle Spiders | R | 139.0 | 39 | 39 | 19 | 17 | 3.63 | .267 | 1.07 | 7.9 | 1.7 | 7.7 | 295.1 | 260 | 125 | 119 | 36 | 57 | 254 | 11 | 0 | 0 | 2 | 25 | 6 | 6 | 3.51 |
| SP | Newhouser, H.Newhouser, Hal | Pit Pirates | L | 136.0 | 22 | 22 | 15 | 4 | 2.13 | .277 | 1.13 | 6.8 | 3.4 | 6.4 | 168.2 | 127 | 49 | 40 | 14 | 64 | 119 | 6 | 0 | 0 | 1 | 19 | 3 | 3 | 3.86 |
| SP | Sweeney, C.Sweeney, Charlie | Phi Quakers | R | 123.0 | 35 | 35 | 15 | 10 | 3.76 | .283 | 1.15 | 7.9 | 2.5 | 4.9 | 273.0 | 239 | 123 | 114 | 32 | 75 | 150 | 16 | 0 | 0 | 3 | 18 | 9 | 7 | 4.35 |
| SP | Alexander, P.Alexander, Pete | NY Mets | R | 118.0 | 36 | 36 | 14 | 16 | 3.22 | .277 | 1.13 | 7.8 | 2.3 | 4.9 | 279.2 | 243 | 117 | 100 | 26 | 72 | 152 | 12 | 0 | 0 | 1 | 25 | 6 | 5 | 3.96 |
| SP | Verlander, J.Verlander, Justin | NY Mets | R | 114.0 | 36 | 36 | 13 | 12 | 3.18 | .264 | 1.05 | 7.4 | 2.1 | 8.4 | 254.1 | 208 | 94 | 90 | 25 | 59 | 238 | 2 | 0 | 0 | 1 | 20 | 6 | 2 | 3.17 |
| SP | Kershaw, C.Kershaw, Clayton | Phi Quakers | L | 113.0 | 36 | 36 | 14 | 12 | 3.67 | .279 | 1.14 | 7.9 | 2.5 | 8.2 | 257.2 | 225 | 114 | 105 | 26 | 70 | 235 | 9 | 0 | 0 | 2 | 22 | 4 | 6 | 3.35 |