Playoff Series Breakdown
| First Round Playoff: Red Sox @ White Sox | ||
| 1 | White Sox 3, Red Sox 1 | WP: Giolito LP: Osuna |
| 2 | Red Sox @ White Sox | |
| 3 | White Sox @ Red Sox | |
| 4 | White Sox @ Red Sox | |
| 5 | White Sox @ Red Sox | |
| 6 | Red Sox @ White Sox | |
| 7 | Red Sox @ White Sox | |
| White Sox Lead Series 1-0 | ||
| First Round Playoff: Guardians @ Orioles | ||
| 1 | Orioles 8, Guardians 2 | WP: Suarez LP: Bauer |
| 2 | Guardians @ Orioles | |
| 3 | Orioles @ Guardians | |
| 4 | Orioles @ Guardians | |
| 5 | Orioles @ Guardians | |
| 6 | Guardians @ Orioles | |
| 7 | Guardians @ Orioles | |
| Orioles Lead Series 1-0 | ||
| First Round Playoff: Braves @ Cubs | ||
| 1 | Cubs 5, Braves 1 | WP: Wacha LP: Wood |
| 2 | Braves @ Cubs | |
| 3 | Cubs @ Braves | |
| 4 | Cubs @ Braves | |
| 5 | Cubs @ Braves | |
| 6 | Braves @ Cubs | |
| 7 | Braves @ Cubs | |
| Cubs Lead Series 1-0 | ||
| First Round Playoff: Nationals @ Dodgers | ||
| 1 | Dodgers 5, Nationals 3 | WP: Buehler LP: Strasburg |
| 2 | Nationals @ Dodgers | |
| 3 | Dodgers @ Nationals | |
| 4 | Dodgers @ Nationals | |
| 5 | Dodgers @ Nationals | |
| 6 | Nationals @ Dodgers | |
| 7 | Nationals @ Dodgers | |
| Dodgers Lead Series 1-0 | ||
