| SP | Giolito, L.Giolito, Lucas | 27 | White Sox | R | 181.0 | 33 | 33 | 22 | 6 | 2.34 | .261 | 1.05 | 6.4 | 3.1 | 10.3 | 215.1 | 153 | 64 | 56 | 21 | 73 | 247 | 0 | 0 | 0 | 0 | 21 | 2 | 7 | 3.02 |
| SP | Verlander, J.Verlander, Justin | 39 | Tigers | R | 131.0 | 33 | 33 | 17 | 8 | 3.33 | .290 | 1.16 | 7.9 | 2.6 | 9.7 | 221.2 | 193 | 86 | 82 | 18 | 65 | 238 | 2 | 0 | 0 | 1 | 19 | 14 | 2 | 2.98 |
| SP | Cabrera, E.Cabrera, Edward | 24 | Orioles | R | 114.0 | 32 | 32 | 14 | 5 | 2.94 | .287 | 1.19 | 6.7 | 4.0 | 9.3 | 174.2 | 129 | 58 | 57 | 18 | 78 | 180 | 0 | 0 | 0 | 0 | 11 | 4 | 2 | 3.69 |
| SP | Bieber, S.Bieber, Shane + | 27 | Guardians | R | 111.0 | 33 | 33 | 14 | 10 | 3.59 | .286 | 1.18 | 7.4 | 3.2 | 11.0 | 220.2 | 182 | 88 | 88 | 23 | 79 | 269 | 3 | 0 | 0 | 2 | 20 | 4 | 9 | 3.05 |
| SP | Scherzer, M.Scherzer, Max | 38 | Tigers | R | 102.0 | 33 | 33 | 16 | 11 | 3.91 | .288 | 1.19 | 8.5 | 2.2 | 9.7 | 207.0 | 196 | 96 | 90 | 42 | 51 | 223 | 1 | 0 | 0 | 0 | 20 | 4 | 3 | 4.28 |