Playoff Series Breakdown
| First Round Playoff: White Sox @ Reds | ||
| 1 | Reds 3, White Sox 1 | WP: Crochet LP: Sheehan |
| 2 | White Sox 3, Reds 1 | WP: Scherzer LP: May |
| 3 | White Sox 9, Reds 5 | WP: Yamamoto LP: Greene |
| 4 | White Sox 7, Reds 0 | WP: Glasnow LP: Buehler |
| White Sox Win Series 3-1 | ||
| First Round Playoff: Tigers @ Cardinals | ||
| 1 | Cardinals 5, Tigers 3 | WP: Wainwright LP: Skubal |
| 2 | Cardinals 2, Tigers 1 | WP: Rogers LP: Olson |
| 3 | Tigers 2, Cardinals 0 | WP: Buehler LP: Burnes |
| 4 | Tigers 6, Cardinals 4 | WP: Melton LP: Svanson |
| 5 | Cardinals 7, Tigers 5 | WP: Wells LP: Hoffman |
| Cardinals Win Series 3-2 | ||
| Second Round Playoff: Cardinals @ White Sox | ||
| 1 | Cardinals 4, White Sox 1 | WP: Rogers LP: Sheehan |
| 2 | White Sox 10, Cardinals 3 | WP: Yamamoto LP: Burnes |
| 3 | White Sox 4, Cardinals 1 | WP: Scherzer LP: Bradish |
| 4 | Cardinals 5, White Sox 2 | WP: Cease LP: Glasnow |
| 5 | White Sox 8, Cardinals 4 | WP: Sheehan LP: Rogers |
| 6 | Cardinals 11, White Sox 1 | WP: Burnes LP: Yamamoto |
| 7 | White Sox 2, Cardinals 0 | WP: Scherzer LP: Bradish |
| White Sox Win Series 4-3 | ||
| World Series: White Sox @ Yankees | ||
| 1 | White Sox 6, Yankees 2 | WP: Sheehan LP: Schlittler |
| 2 | Yankees 2, White Sox 1 | WP: Skenes LP: Hendriks |
| 3 | Yankees 7, White Sox 1 | WP: Cortes Jr. LP: Scherzer |
| 4 | White Sox 9, Yankees 3 | WP: Glasnow LP: Gil |
| 5 | White Sox 5, Yankees 4 | WP: Bauer LP: Schlittler |
| 6 | White Sox 7, Yankees 1 | WP: Yamamoto LP: Skenes |
| White Sox Win Series 4-2 | ||
