| SP | Yamamoto, Y.Yamamoto, Yoshinobu | White Sox | R | 120.0 | 38 | 38 | 16 | 10 | 3.79 | .293 | 1.18 | 7.1 | 3.5 | 11.6 | 235.0 | 186 | 103 | 99 | 29 | 92 | 302 | 2 | 0 | 0 | 2 | 24 | 14 | 7 | 3.39 |
| CL | Stephenson, R.Stephenson, Robert # | Yankees | R | 119.0 | 69 | 0 | 7 | 11 | 3.75 | .297 | 1.18 | 7.1 | 3.6 | 11.6 | 74.1 | 58 | 32 | 31 | 6 | 30 | 95 | 0 | 38 | 6 | 0 | 0 | 6 | 4 | 2.95 |
| SP | Glasnow, T.Glasnow, Tyler # | White Sox | R | 117.0 | 35 | 35 | 17 | 10 | 3.66 | .299 | 1.23 | 7.5 | 3.6 | 11.1 | 211.2 | 175 | 87 | 86 | 22 | 85 | 260 | 0 | 0 | 0 | 0 | 20 | 11 | 13 | 3.26 |
| SP | Cortes Jr., N.Cortes Jr., Nestor | Yankees | L | 111.0 | 33 | 33 | 15 | 7 | 3.75 | .283 | 1.15 | 8.0 | 2.4 | 11.0 | 213.2 | 190 | 93 | 89 | 30 | 56 | 261 | 0 | 0 | 0 | 0 | 21 | 7 | 3 | 3.27 |
| SP | Rogers, T.Rogers, Trevor # | Cardinals | L | 107.0 | 36 | 36 | 18 | 12 | 4.07 | .294 | 1.24 | 8.0 | 3.1 | 9.6 | 223.1 | 199 | 103 | 101 | 32 | 77 | 239 | 0 | 0 | 0 | 0 | 24 | 3 | 0 | 3.80 |
| SP | Scherzer, M.Scherzer, Max | White Sox | R | 103.0 | 36 | 36 | 15 | 12 | 3.69 | .281 | 1.14 | 7.8 | 2.4 | 10.7 | 212.1 | 184 | 91 | 87 | 31 | 57 | 253 | 1 | 0 | 0 | 0 | 20 | 8 | 3 | 3.43 |
| CL | Chapman, A.Chapman, Aroldis | Reds | L | 102.5 | 59 | 0 | 1 | 3 | 3.55 | .321 | 1.36 | 6.3 | 6.1 | 9.7 | 50.2 | 35 | 20 | 20 | 7 | 34 | 54 | 0 | 39 | 5 | 0 | 0 | 3 | 3 | 4.88 |
| SP | Crochet, G.Crochet, Garrett # | Reds | L | 90.0 | 33 | 33 | 12 | 9 | 4.09 | .283 | 1.14 | 8.1 | 2.2 | 11.1 | 220.0 | 198 | 106 | 100 | 43 | 53 | 271 | 3 | 0 | 0 | 1 | 17 | 9 | 6 | 3.92 |