| SP | Yamamoto, Y.Yamamoto, Yoshinobu | 30 | White Sox | R | 120.0 | 38 | 38 | 16 | 10 | 3.79 | .293 | 1.18 | 7.1 | 3.5 | 11.6 | 235.0 | 186 | 103 | 99 | 29 | 92 | 302 | 2 | 0 | 0 | 2 | 24 | 14 | 7 | 3.39 |
| SP | Glasnow, T.Glasnow, Tyler # | 27 | White Sox | R | 117.0 | 35 | 35 | 17 | 10 | 3.66 | .299 | 1.23 | 7.5 | 3.6 | 11.1 | 211.2 | 175 | 87 | 86 | 22 | 85 | 260 | 0 | 0 | 0 | 0 | 20 | 11 | 13 | 3.26 |
| SP | Cortes Jr., N.Cortes Jr., Nestor | 28 | Yankees | L | 111.0 | 33 | 33 | 15 | 7 | 3.75 | .283 | 1.15 | 8.0 | 2.4 | 11.0 | 213.2 | 190 | 93 | 89 | 30 | 56 | 261 | 0 | 0 | 0 | 0 | 21 | 7 | 3 | 3.27 |
| SP | Rogers, T.Rogers, Trevor # | 31 | Cardinals | L | 107.0 | 36 | 36 | 18 | 12 | 4.07 | .294 | 1.24 | 8.0 | 3.1 | 9.6 | 223.1 | 199 | 103 | 101 | 32 | 77 | 239 | 0 | 0 | 0 | 0 | 24 | 3 | 0 | 3.80 |
| SP | Scherzer, M.Scherzer, Max | 37 | White Sox | R | 103.0 | 36 | 36 | 15 | 12 | 3.69 | .281 | 1.14 | 7.8 | 2.4 | 10.7 | 212.1 | 184 | 91 | 87 | 31 | 57 | 253 | 1 | 0 | 0 | 0 | 20 | 8 | 3 | 3.43 |
| SP | Crochet, G.Crochet, Garrett # | 30 | Reds | L | 90.0 | 33 | 33 | 12 | 9 | 4.09 | .283 | 1.14 | 8.1 | 2.2 | 11.1 | 220.0 | 198 | 106 | 100 | 43 | 53 | 271 | 3 | 0 | 0 | 1 | 17 | 9 | 6 | 3.92 |
| SP | McKenzie, T.McKenzie, Triston | 25 | Braves | R | 84.0 | 33 | 33 | 11 | 11 | 3.75 | .303 | 1.28 | 8.6 | 3.0 | 10.5 | 213.2 | 203 | 93 | 89 | 24 | 70 | 248 | 2 | 0 | 0 | 0 | 21 | 5 | 13 | 3.19 |
| SP | Buehler, W.Buehler, Walker | 25 | Reds | R | 81.0 | 33 | 33 | 14 | 11 | 4.29 | .300 | 1.26 | 8.5 | 2.9 | 9.1 | 210.0 | 198 | 100 | 100 | 32 | 67 | 212 | 0 | 0 | 0 | 0 | 17 | 5 | 6 | 3.99 |