| SP | Yamamoto, Y.Yamamoto, Yoshinobu | 30 | White Sox | R | 95 | 38 | 38 | 16 | 10 | 3.79 | .293 | 1.18 | 7.1 | 3.5 | 11.6 | 235.0 | 186 | 103 | 99 | 29 | 92 | 302 | 2 | 0 | 0 | 2 | 24 | 14 | 7 | 3.39 |
| SP | May, D.May, Dustin | 27 | Reds | R | 97 | 36 | 36 | 10 | 12 | 3.79 | .290 | 1.18 | 6.9 | 3.7 | 7.4 | 225.1 | 172 | 97 | 95 | 30 | 93 | 185 | 0 | 0 | 0 | 0 | 21 | 11 | 3 | 4.48 |
| SP | Rogers, T.Rogers, Trevor # | 31 | Cardinals | L | 89 | 36 | 36 | 18 | 12 | 4.07 | .294 | 1.24 | 8.0 | 3.1 | 9.6 | 223.1 | 199 | 103 | 101 | 32 | 77 | 239 | 0 | 0 | 0 | 0 | 24 | 3 | 0 | 3.80 |
| SP | Crochet, G.Crochet, Garrett # | 30 | Reds | L | 76 | 33 | 33 | 12 | 9 | 4.09 | .283 | 1.14 | 8.1 | 2.2 | 11.1 | 220.0 | 198 | 106 | 100 | 43 | 53 | 271 | 3 | 0 | 0 | 1 | 17 | 9 | 6 | 3.92 |
| SP | Skenes, P.Skenes, Paul | 25 | Yankees | R | 86 | 35 | 35 | 12 | 14 | 4.24 | .294 | 1.22 | 8.0 | 3.0 | 10.9 | 218.2 | 193 | 107 | 103 | 38 | 73 | 264 | 1 | 0 | 0 | 0 | 18 | 7 | 5 | 3.94 |
| SP | Schlittler, C.Schlittler, Cam # | 28 | Yankees | R | 94 | 36 | 36 | 9 | 7 | 4.30 | .301 | 1.22 | 8.4 | 2.6 | 10.1 | 215.1 | 201 | 109 | 103 | 28 | 61 | 241 | 0 | 0 | 0 | 0 | 16 | 16 | 8 | 3.53 |
| SP | Waldrep, H.Waldrep, Hurston | 27 | Braves | R | 93 | 34 | 34 | 12 | 12 | 4.30 | .304 | 1.25 | 8.5 | 2.8 | 8.2 | 215.1 | 202 | 107 | 103 | 30 | 68 | 196 | 0 | 0 | 0 | 0 | 20 | 12 | 0 | 4.11 |
| SP | Skubal, T.Skubal, Tarik | 28 | Tigers | L | 88 | 37 | 37 | 11 | 13 | 4.28 | .288 | 1.20 | 8.1 | 2.8 | 10.4 | 214.2 | 192 | 103 | 102 | 24 | 66 | 247 | 0 | 0 | 0 | 0 | 18 | 3 | 1 | 3.12 |
| SP | McKenzie, T.McKenzie, Triston | 25 | Braves | R | 80 | 33 | 33 | 11 | 11 | 3.75 | .303 | 1.28 | 8.6 | 3.0 | 10.5 | 213.2 | 203 | 93 | 89 | 24 | 70 | 248 | 2 | 0 | 0 | 0 | 21 | 5 | 13 | 3.19 |
| SP | Cortes Jr., N.Cortes Jr., Nestor | 28 | Yankees | L | 85 | 33 | 33 | 15 | 7 | 3.75 | .283 | 1.15 | 8.0 | 2.4 | 11.0 | 213.2 | 190 | 93 | 89 | 30 | 56 | 261 | 0 | 0 | 0 | 0 | 21 | 7 | 3 | 3.27 |
| SP | Nola, A.Nola, Aaron | 30 | Tigers | R | 64 | 33 | 33 | 11 | 8 | 4.22 | .317 | 1.35 | 10.0 | 2.2 | 11.0 | 213.1 | 237 | 104 | 100 | 25 | 51 | 260 | 1 | 0 | 0 | 0 | 17 | 9 | 1 | 2.93 |
| SP | Scherzer, M.Scherzer, Max | 37 | White Sox | R | 96 | 36 | 36 | 15 | 12 | 3.69 | .281 | 1.14 | 7.8 | 2.4 | 10.7 | 212.1 | 184 | 91 | 87 | 31 | 57 | 253 | 1 | 0 | 0 | 0 | 20 | 8 | 3 | 3.43 |
| SP | Glasnow, T.Glasnow, Tyler # | 27 | White Sox | R | 91 | 35 | 35 | 17 | 10 | 3.66 | .299 | 1.23 | 7.5 | 3.6 | 11.1 | 211.2 | 175 | 87 | 86 | 22 | 85 | 260 | 0 | 0 | 0 | 0 | 20 | 11 | 13 | 3.26 |
| SP | Buehler, W.Buehler, Walker | 25 | Reds | R | 79 | 33 | 33 | 14 | 11 | 4.29 | .300 | 1.26 | 8.5 | 2.9 | 9.1 | 210.0 | 198 | 100 | 100 | 32 | 67 | 212 | 0 | 0 | 0 | 0 | 17 | 5 | 6 | 3.99 |
| SP | Greene, H.Greene, Hunter | 27 | Reds | R | 78 | 35 | 35 | 11 | 12 | 4.08 | .323 | 1.37 | 7.4 | 5.0 | 9.7 | 209.1 | 172 | 97 | 95 | 23 | 115 | 226 | 1 | 0 | 0 | 0 | 16 | 13 | 14 | 4.11 |
| SP | Sheehan, E.Sheehan, Emmet | 29 | White Sox | R | 100 | 38 | 38 | 13 | 13 | 4.53 | .301 | 1.25 | 8.5 | 2.7 | 10.9 | 208.2 | 197 | 106 | 105 | 35 | 63 | 253 | 0 | 0 | 0 | 0 | 19 | 10 | 6 | 3.81 |
| SP | Buehler, W.Buehler, Walker | 26 | Tigers | R | 67 | 33 | 33 | 11 | 11 | 4.24 | .334 | 1.44 | 9.7 | 3.3 | 9.5 | 201.2 | 216 | 98 | 95 | 22 | 74 | 213 | 1 | 0 | 0 | 0 | 17 | 14 | 4 | 3.62 |
| SP | Bradish, K.Bradish, Kyle # | 30 | Cardinals | R | 92 | 37 | 37 | 7 | 10 | 3.51 | .313 | 1.35 | 7.9 | 4.3 | 11.2 | 197.2 | 173 | 81 | 77 | 22 | 94 | 245 | 0 | 0 | 0 | 0 | 12 | 3 | 9 | 3.44 |
| SP | Burnes, C.Burnes, Corbin | 26 | Cardinals | R | 81 | 35 | 35 | 9 | 11 | 5.79 | .341 | 1.51 | 10.8 | 2.8 | 11.4 | 197.1 | 236 | 130 | 127 | 31 | 62 | 250 | 0 | 0 | 0 | 0 | 12 | 9 | 3 | 3.59 |
| SP | Olson, R.Olson, Reese | 29 | Tigers | R | 83 | 35 | 35 | 13 | 12 | 4.78 | .327 | 1.44 | 9.6 | 3.4 | 8.5 | 196.0 | 209 | 108 | 104 | 31 | 74 | 185 | 0 | 0 | 0 | 0 | 16 | 3 | 8 | 4.35 |
| SP | Verlander, J.Verlander, Justin # | 40 | Giants | R | 89 | 33 | 33 | 10 | 8 | 5.11 | .321 | 1.39 | 10.2 | 2.4 | 11.1 | 190.1 | 215 | 112 | 108 | 29 | 50 | 234 | 0 | 0 | 0 | 0 | 15 | 5 | 2 | 3.39 |
| SP | Castillo, L.Castillo, Luis | 30 | Reds | R | 45 | 32 | 32 | 10 | 12 | 4.37 | .299 | 1.24 | 8.2 | 2.9 | 10.7 | 189.1 | 173 | 93 | 92 | 28 | 61 | 224 | 1 | 0 | 0 | 1 | 14 | 8 | 0 | 3.65 |
| SP | Flaherty, J.Flaherty, Jack # | 31 | Tigers | R | 55 | 32 | 32 | 11 | 14 | 4.25 | .304 | 1.26 | 8.4 | 3.0 | 10.7 | 188.2 | 175 | 94 | 89 | 23 | 62 | 224 | 0 | 0 | 0 | 0 | 19 | 10 | 3 | 3.36 |
| SP | Ray, R.Ray, Robbie | 29 | Giants | L | 57 | 32 | 32 | 11 | 13 | 4.63 | .321 | 1.38 | 9.3 | 3.1 | 10.2 | 188.2 | 195 | 104 | 97 | 20 | 65 | 214 | 0 | 0 | 0 | 0 | 18 | 7 | 9 | 3.26 |
| SP | Berrios, J.Berrios, Jose | 27 | Cubs | R | 45 | 32 | 32 | 9 | 11 | 4.27 | .322 | 1.38 | 9.0 | 3.5 | 9.6 | 185.1 | 184 | 93 | 88 | 27 | 71 | 198 | 0 | 0 | 0 | 0 | 15 | 9 | 4 | 4.05 |
| SP | Severino, L.Severino, Luis | 29 | Giants | R | 84 | 33 | 33 | 9 | 16 | 5.20 | .314 | 1.36 | 9.3 | 2.9 | 9.7 | 185.1 | 192 | 111 | 107 | 30 | 60 | 199 | 0 | 0 | 0 | 0 | 11 | 3 | 6 | 3.98 |
| SP | Horton, C.Horton, Cade | 27 | Cubs | R | 66 | 33 | 33 | 5 | 15 | 4.30 | .330 | 1.46 | 9.8 | 3.3 | 8.5 | 184.0 | 201 | 98 | 88 | 24 | 68 | 174 | 0 | 0 | 0 | 0 | 11 | 3 | 2 | 3.96 |
| SP | Cease, D.Cease, Dylan # | 27 | Cardinals | R | 62 | 33 | 33 | 11 | 8 | 4.85 | .334 | 1.45 | 8.7 | 4.5 | 11.7 | 183.2 | 176 | 102 | 99 | 18 | 91 | 237 | 0 | 0 | 0 | 0 | 12 | 9 | 2 | 3.33 |
| SP | Gonsolin, T.Gonsolin, Tony | 29 | White Sox | R | 98 | 32 | 32 | 9 | 10 | 3.86 | .314 | 1.35 | 8.1 | 4.1 | 9.0 | 181.2 | 163 | 87 | 78 | 18 | 83 | 181 | 0 | 0 | 0 | 0 | 16 | 4 | 7 | 3.73 |
| SP | Luzardo, J.Luzardo, Jesus | 25 | Cardinals | L | 53 | 32 | 32 | 12 | 11 | 4.00 | .298 | 1.23 | 7.7 | 3.4 | 11.4 | 180.0 | 153 | 82 | 80 | 23 | 68 | 228 | 0 | 0 | 0 | 0 | 13 | 8 | 5 | 3.39 |