| SP | Peralta, F.Peralta, Freddy >> | 26 | 2021 | R | 98 | 10 | 5 | 2.81 | .236 | .310 | 0.95 | 5.1 | 3.4 | 12.2 | 147 | 84 | 14 | 55 | 200 | 1 | 0 | 4 | 96 | 23 | C |
| SP | Burnes, C.Burnes, Corbin >> | 27 | 2021 | R | 95 | 11 | 5 | 2.43 | .226 | .300 | 0.90 | 6.4 | 1.6 | 12.4 | 172 | 123 | 7 | 31 | 237 | 0 | 0 | 5 | 110 | 24 | C |
| SP | Woodruff, B.Woodruff, Brandon >> | 29 | 2021 | R | 94 | 9 | 10 | 2.56 | .230 | .300 | 0.91 | 6.4 | 1.9 | 10.7 | 184 | 130 | 18 | 38 | 219 | 0 | 0 | 2 | 108 | 22 | C |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 86 | 16 | 8 | 2.13 | .243 | .310 | 0.98 | 6.7 | 2.1 | 8.1 | 190 | 142 | 15 | 44 | 170 | 2 | 0 | 5 | 108 | 18 | C |
| SP | Sheets, B.Sheets, Ben >> | 27 | 2004 | R | 87 | 12 | 14 | 2.70 | .237 | .310 | 0.95 | 7.5 | 1.0 | 10.1 | 241 | 201 | 25 | 27 | 270 | 5 | 0 | 8 | 126 | 21 | C |
| RP | Hader, J.Hader, Josh >> | 28 | 2021 | L | 100 | 4 | 2 | 1.23 | .188 | .260 | 0.73 | 3.6 | 3.0 | 15.6 | 63 | 25 | 3 | 21 | 109 | 0 | 34 | 3 | 25 | 28 | C |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 99 | 0 | 1 | 3.75 | .197 | .280 | 0.81 | 3.8 | 3.5 | 13.0 | 36 | 15 | 4 | 14 | 52 | 0 | 2 | 5 | 23 | 23 | C |
| RP | Chapman, A.Chapman, Aroldis >> | 28 | 2016 | L | 97 | 4 | 1 | 1.55 | .214 | .290 | 0.86 | 5.0 | 2.8 | 14.0 | 58 | 32 | 2 | 18 | 90 | 0 | 36 | 8 | 23 | 25 | C |
| RP | Richards, T.Richards, Trevor >> | 29 | 2021 | R | 96 | 7 | 2 | 3.50 | .216 | .290 | 0.87 | 5.4 | 2.4 | 11.3 | 67 | 40 | 12 | 18 | 84 | 0 | 1 | 8 | 27 | 22 | C |
| RP | Strop, P.Strop, Pedro >> | 31 | 2016 | R | 95 | 2 | 2 | 2.85 | .218 | .300 | 0.89 | 5.2 | 2.9 | 11.5 | 47 | 27 | 4 | 15 | 60 | 0 | 0 | 7 | 23 | 22 | C |
| RP | Williams, D.Williams, Devin >> | 27 | 2021 | R | 91 | 8 | 2 | 2.50 | .240 | .320 | 1.00 | 5.4 | 3.6 | 13.2 | 60 | 36 | 5 | 24 | 88 | 0 | 3 | 2 | 25 | 25 | C |
| RP | Plesac, D.Plesac, Dan >> | 26 | 1987 | L | 86 | 5 | 6 | 2.61 | .238 | .310 | 0.98 | 6.8 | 2.0 | 10.5 | 83 | 63 | 8 | 18 | 97 | 0 | 23 | 6 | 30 | 22 | C |
| RP | Rasmussen, D.Rasmussen, Drew >> | 26 | 2021 | R | 83 | 4 | 1 | 2.84 | .245 | .320 | 1.01 | 6.7 | 2.5 | 9.2 | 77 | 57 | 5 | 21 | 79 | 0 | 1 | 4 | 43 | 20 | C |
| SP | Lauer, E.Lauer, Eric >> | 27 | 2021 | L | 78 | 7 | 5 | 3.19 | .267 | .340 | 1.13 | 7.1 | 3.0 | 9.5 | 119 | 94 | 16 | 40 | 125 | 0 | 0 | 2 | 90 | 20 | C |
| SP | Hammel, J.Hammel, Jason >> | 34 | 2016 | R | 60 | 15 | 10 | 3.83 | .283 | .360 | 1.21 | 8.0 | 2.9 | 7.8 | 166 | 148 | 25 | 53 | 144 | 0 | 0 | 9 | 98 | 18 | C |
| RP | Boxberger, B.Boxberger, Brad >> | 34 | 2021 | R | 77 | 5 | 4 | 3.34 | .265 | .340 | 1.14 | 6.3 | 3.9 | 10.8 | 64 | 45 | 8 | 28 | 77 | 0 | 4 | 3 | 22 | 20 | C |
| SP | Houser, A.Houser, Adrian >> | 29 | 2021 | R | 66 | 10 | 6 | 3.22 | .282 | .360 | 1.21 | 7.3 | 3.6 | 6.8 | 146 | 118 | 12 | 58 | 110 | 1 | 0 | 9 | 95 | 18 | C |
| SP | Lackey, J.Lackey, John >> | 38 | 2016 | R | 83 | 11 | 8 | 3.35 | .257 | .330 | 1.06 | 7.0 | 2.5 | 8.6 | 188 | 146 | 23 | 53 | 180 | 0 | 0 | 4 | 114 | 19 | C |
| SP | Lester, J.Lester, Jon >> | 32 | 2016 | L | 85 | 19 | 5 | 2.44 | .251 | .320 | 1.02 | 6.9 | 2.3 | 8.8 | 202 | 154 | 21 | 52 | 197 | 2 | 0 | 4 | 111 | 18 | C |
| RP | Curtiss, J.Curtiss, John >> | 29 | 2021 | R | 71 | 3 | 1 | 3.45 | .252 | .330 | 1.08 | 7.6 | 2.2 | 8.6 | 50 | 42 | 6 | 12 | 48 | 0 | 0 | 1 | 25 | 22 | C |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 82 | 2 | 3 | 3.53 | .235 | .310 | 0.98 | 7.4 | 1.4 | 10.2 | 51 | 42 | 8 | 8 | 58 | 0 | 18 | 3 | 23 | 21 | C |
| RP | Cahill, T.Cahill, Trevor >> | 28 | 2016 | R | 61 | 4 | 4 | 2.74 | .291 | .370 | 1.29 | 6.8 | 4.8 | 9.1 | 65 | 49 | 7 | 35 | 66 | 0 | 0 | 3 | 26 | 19 | C |
| RP | Wood, T.Wood, Travis >> | 29 | 2016 | L | 71 | 4 | 0 | 2.95 | .263 | .340 | 1.13 | 6.6 | 3.5 | 6.9 | 61 | 45 | 8 | 24 | 47 | 0 | 0 | 0 | 23 | 17 | C |
| RP | Fingers, R.Fingers, Rollie >> | 36 | 1981 | R | 78 | 6 | 3 | 1.04 | .240 | .320 | 0.99 | 7.2 | 1.7 | 6.9 | 78 | 62 | 3 | 15 | 60 | 0 | 28 | 1 | 29 | 16 | C |
| RP | Feyereisen, J.Feyereisen, J.P. >> | 29 | 2021 | R | 80 | 4 | 4 | 2.73 | .264 | .340 | 1.14 | 5.5 | 4.7 | 9.3 | 59 | 36 | 5 | 31 | 61 | 0 | 3 | 3 | 25 | 19 | C |
| RP | Montgomery, M.Montgomery, Mike >> | 26 | 2016 | L | 67 | 4 | 5 | 2.52 | .274 | .350 | 1.17 | 7.1 | 3.4 | 8.3 | 100 | 79 | 8 | 38 | 92 | 0 | 0 | 10 | 39 | 18 | C |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 84 | 18 | 8 | 3.10 | .263 | .330 | 1.09 | 6.3 | 3.5 | 8.7 | 197 | 138 | 16 | 76 | 190 | 1 | 0 | 16 | 112 | 19 | C |