| SP | Seaver, T.Seaver, Tom + >> | 33 | 1968 | R | 84 | 29 | 29 | 7 | 20 | 4.74 | .303 | 1.30 | 9.2 | 2.5 | 6.0 | 203.0 | 208 | 124 | 107 | 39 | 56 | 136 | 13 | 0 | 0 | 2 | 13 | 1 | 5 | 5.00 |
| SP | Maddux, G.Maddux, Greg >> | 35 | 1992 | R | 71 | 29 | 29 | 8 | 16 | 3.58 | .292 | 1.21 | 8.1 | 2.9 | 5.4 | 229.0 | 205 | 105 | 91 | 30 | 73 | 138 | 10 | 0 | 0 | 0 | 18 | 6 | 4 | 4.53 |
| SP | Zambrano, C.Zambrano, Carlos >> | 37 | 2005 | R | 54 | 28 | 28 | 11 | 11 | 3.48 | .292 | 1.24 | 7.8 | 3.4 | 6.4 | 196.2 | 170 | 86 | 76 | 31 | 73 | 140 | 4 | 0 | 0 | 0 | 18 | 0 | 4 | 4.74 |
| SP | Ellsworth, D.Ellsworth, Dick >> | 41 | 1963 | L | 42 | 28 | 28 | 3 | 22 | 7.79 | .380 | 1.83 | 12.3 | 4.2 | 4.4 | 143.1 | 196 | 142 | 124 | 32 | 66 | 70 | 3 | 0 | 0 | 0 | 6 | 1 | 7 | 6.34 |
| RP | Bummer, A.Bummer, Aaron >> | 41 | 2019 | L | 18 | 50 | 0 | 0 | 2 | 4.18 | .378 | 1.76 | 10.1 | 5.9 | 5.3 | 32.1 | 36 | 20 | 15 | 4 | 21 | 19 | 0 | 3 | 0 | 0 | 0 | 2 | 1 | 5.59 |
| RP | Hobbie, G.Hobbie, Glen >> | 24 | 1958 | R | 27 | 50 | 0 | 4 | 3 | 4.37 | .315 | 1.37 | 7.4 | 5.0 | 4.4 | 78.1 | 64 | 43 | 38 | 7 | 43 | 38 | 0 | 5 | 3 | 0 | 0 | 1 | 0 | 4.88 |
| RP | Arano, V.Arano, Victor >> | 40 | 2018 | R | 8 | 35 | 0 | 1 | 2 | 4.36 | .327 | 1.45 | 10.9 | 2.2 | 4.6 | 33.0 | 40 | 16 | 16 | 3 | 8 | 17 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.88 |
| SP | Buehrle, M.Buehrle, Mark >> | 39 | 2001 | L | 40 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Arrieta, J.Arrieta, Jake >> | 46 | 2015 | R | 44 | 1 | 0 | 1 | 0 | 1.50 | .217 | 0.83 | 6.0 | 1.5 | 7.5 | 6.0 | 4 | 1 | 1 | 0 | 1 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.83 |
| SP | Giolito, L.Giolito, Lucas >> | 40 | 2019 | R | 39 | 14 | 0 | 0 | 2 | 5.48 | .324 | 1.43 | 9.8 | 3.1 | 9.0 | 23.0 | 25 | 14 | 14 | 3 | 8 | 23 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.74 |