| SP | Seaver, T.Seaver, Tom + >> | 33 | 1968 | R | 84 | 18 | 18 | 6 | 11 | 4.65 | .299 | 1.28 | 9.1 | 2.4 | 6.5 | 129.2 | 131 | 81 | 67 | 29 | 35 | 93 | 8 | 0 | 0 | 1 | 8 | 0 | 3 | 5.29 |
| SP | Maddux, G.Maddux, Greg >> | 35 | 1992 | R | 71 | 18 | 18 | 3 | 12 | 3.88 | .302 | 1.27 | 8.5 | 2.8 | 5.6 | 139.0 | 132 | 65 | 60 | 15 | 44 | 86 | 6 | 0 | 0 | 0 | 11 | 4 | 2 | 4.20 |
| SP | Zambrano, C.Zambrano, Carlos >> | 37 | 2005 | R | 54 | 18 | 18 | 7 | 7 | 3.37 | .302 | 1.30 | 8.0 | 3.7 | 6.5 | 125.2 | 111 | 56 | 47 | 17 | 52 | 90 | 1 | 0 | 0 | 0 | 13 | 0 | 2 | 4.58 |
| SP | Ellsworth, D.Ellsworth, Dick >> | 41 | 1963 | L | 42 | 18 | 18 | 1 | 15 | 7.77 | .392 | 1.93 | 13.1 | 4.3 | 4.6 | 90.1 | 131 | 94 | 78 | 21 | 43 | 46 | 2 | 0 | 0 | 0 | 4 | 1 | 5 | 6.48 |
| RP | Bummer, A.Bummer, Aaron >> | 41 | 2019 | L | 18 | 31 | 0 | 0 | 2 | 3.79 | .387 | 1.79 | 10.4 | 5.7 | 5.7 | 19.0 | 22 | 13 | 8 | 2 | 12 | 12 | 0 | 3 | 0 | 0 | 0 | 2 | 0 | 5.32 |
| RP | Hobbie, G.Hobbie, Glen >> | 24 | 1958 | R | 27 | 32 | 0 | 1 | 3 | 4.86 | .332 | 1.47 | 9.2 | 4.1 | 5.1 | 46.1 | 47 | 30 | 25 | 5 | 21 | 26 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 4.72 |
| RP | Arano, V.Arano, Victor >> | 40 | 2018 | R | 8 | 22 | 0 | 1 | 1 | 5.03 | .366 | 1.73 | 13.7 | 2.4 | 3.8 | 19.2 | 29 | 11 | 11 | 2 | 5 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.32 |
| SP | Buehrle, M.Buehrle, Mark >> | 39 | 2001 | L | 40 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Arrieta, J.Arrieta, Jake >> | 46 | 2015 | R | 44 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Giolito, L.Giolito, Lucas >> | 40 | 2019 | R | 39 | 9 | 0 | 0 | 2 | 6.28 | .348 | 1.60 | 10.9 | 3.9 | 10.3 | 14.1 | 17 | 10 | 10 | 2 | 6 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.86 |