| SP | Scherzer, M.Scherzer, Max # >> | 37 | 2021 | R | 99 | 12 | 12 | 5 | 4 | 5.00 | .327 | 1.41 | 9.4 | 3.4 | 9.5 | 66.2 | 69 | 40 | 37 | 9 | 25 | 70 | 0 | 0 | 0 | 0 | 6 | 3 | 0 | 3.92 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 92 | 11 | 11 | 4 | 6 | 4.10 | .307 | 1.33 | 7.7 | 4.2 | 9.2 | 79.0 | 68 | 36 | 36 | 10 | 37 | 81 | 1 | 0 | 0 | 0 | 4 | 0 | 0 | 4.00 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 72 | 11 | 11 | 2 | 4 | 5.30 | .313 | 1.33 | 8.9 | 3.2 | 6.1 | 74.2 | 73 | 44 | 44 | 13 | 26 | 50 | 1 | 0 | 0 | 0 | 4 | 3 | 2 | 5.11 |
| SP | Strasburg, S.Strasburg, Stephen >> | 28 | 2017 | R | 43 | 10 | 10 | 4 | 4 | 4.13 | .315 | 1.31 | 8.3 | 3.5 | 9.7 | 61.0 | 56 | 29 | 28 | 11 | 24 | 66 | 0 | 0 | 0 | 0 | 6 | 4 | 0 | 4.56 |
| SP | Martinez, D.Martinez, Dennis >> | 37 | 1992 | R | 30 | 7 | 7 | 4 | 3 | 5.24 | .340 | 1.54 | 10.4 | 3.7 | 3.7 | 44.2 | 51 | 27 | 26 | 10 | 18 | 18 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 6.36 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 88 | 29 | 0 | 1 | 0 | 3.09 | .281 | 1.14 | 6.7 | 3.6 | 4.6 | 35.0 | 26 | 12 | 12 | 2 | 14 | 18 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.00 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 97 | 17 | 0 | 1 | 1 | 1.65 | .290 | 1.16 | 8.4 | 2.3 | 8.4 | 16.1 | 15 | 3 | 3 | 1 | 4 | 15 | 0 | 14 | 0 | 0 | 0 | 1 | 1 | 2.88 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 70 | 23 | 0 | 3 | 2 | 4.07 | .263 | 1.03 | 5.6 | 3.8 | 10.9 | 24.1 | 15 | 11 | 11 | 7 | 10 | 29 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.75 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 73 | 18 | 0 | 1 | 1 | 4.41 | .269 | 1.10 | 7.3 | 2.8 | 6.8 | 16.1 | 13 | 8 | 8 | 5 | 5 | 12 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 6.50 |
| RP | Albers, M.Albers, Matt >> | 34 | 2017 | R | 69 | 9 | 0 | 0 | 0 | 6.00 | .289 | 1.22 | 9.0 | 2.0 | 9.0 | 9.0 | 9 | 6 | 6 | 2 | 2 | 9 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.56 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 35 | 5 | 0 | 0 | 1 | 7.36 | .313 | 1.36 | 12.0 | 3.0 | 6.0 | 3.2 | 4 | 3 | 3 | 2 | 1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11.33 |
| RP | Rivero, F.Rivero, Felipe >> | 23 | 2015 | L | 19 | 33 | 0 | 0 | 0 | 1.40 | .194 | 0.67 | 3.8 | 2.4 | 4.7 | 19.1 | 8 | 5 | 3 | 1 | 5 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.58 |