| SP | Scherzer, M.Scherzer, Max >> | 37 | 2021 | R | 99 | 9 | 9 | 6 | 1 | 3.51 | .278 | 1.15 | 7.1 | 3.4 | 9.2 | 56.1 | 44 | 22 | 22 | 9 | 21 | 57 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 4.18 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 92 | 8 | 8 | 5 | 3 | 3.13 | .301 | 1.26 | 8.6 | 2.9 | 11.1 | 60.1 | 57 | 21 | 21 | 5 | 19 | 74 | 3 | 0 | 0 | 0 | 7 | 2 | 0 | 2.67 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 71 | 8 | 8 | 3 | 3 | 3.32 | .287 | 1.19 | 8.4 | 2.4 | 4.7 | 59.2 | 55 | 26 | 22 | 8 | 16 | 31 | 2 | 0 | 0 | 1 | 5 | 1 | 0 | 4.58 |
| SP | Rogers, S.Rogers, Steve # >> | 24 | 1973 | R | 41 | 8 | 8 | 3 | 4 | 5.84 | .357 | 1.66 | 9.4 | 5.7 | 5.9 | 49.1 | 51 | 33 | 32 | 7 | 31 | 32 | 0 | 0 | 0 | 0 | 3 | 0 | 1 | 5.45 |
| SP | Strasburg, S.Strasburg, Stephen >> | 24 | 2013 | R | 38 | 6 | 5 | 0 | 2 | 6.04 | .361 | 1.69 | 10.9 | 4.5 | 7.1 | 28.1 | 34 | 19 | 19 | 5 | 14 | 22 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 5.25 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 98 | 20 | 0 | 1 | 0 | 2.13 | .232 | 0.91 | 5.4 | 2.9 | 11.9 | 25.1 | 15 | 6 | 6 | 4 | 8 | 33 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 3.40 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 88 | 19 | 0 | 3 | 0 | 2.67 | .242 | 0.96 | 6.6 | 2.1 | 5.7 | 30.1 | 22 | 14 | 9 | 2 | 7 | 19 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 3.30 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 65 | 12 | 0 | 3 | 0 | 0.00 | .242 | 0.96 | 5.1 | 3.9 | 11.3 | 16.2 | 9 | 1 | 0 | 1 | 7 | 20 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 2.63 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 64 | 7 | 0 | 0 | 1 | 12.60 | .423 | 2.20 | 14.4 | 5.4 | 14.4 | 5.0 | 8 | 7 | 7 | 2 | 3 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.80 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 40 | 3 | 0 | 0 | 0 | 2.45 | .313 | 1.36 | 6.0 | 9.0 | 15.0 | 3.2 | 2 | 1 | 1 | 1 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.00 |
| RP | Valdez, S.Valdez, Sergio >> | 28 | 1992 | R | 17 | 6 | 0 | 0 | 0 | 9.00 | .323 | 1.43 | 7.7 | 5.1 | 11.6 | 7.0 | 6 | 9 | 7 | 3 | 4 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 7.71 |