| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 86 | 12 | 12 | 7 | 3 | 2.74 | .249 | 0.97 | 6.4 | 2.4 | 9.4 | 85.1 | 60 | 28 | 26 | 6 | 23 | 89 | 1 | 0 | 0 | 0 | 9 | 2 | 0 | 2.71 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 81 | 11 | 11 | 5 | 4 | 4.39 | .284 | 1.15 | 8.1 | 2.3 | 6.6 | 84.0 | 76 | 42 | 41 | 8 | 21 | 62 | 6 | 0 | 0 | 0 | 6 | 3 | 1 | 3.62 |
| SP | Scherzer, M.Scherzer, Max # >> | 29 | 2013 | R | 69 | 11 | 11 | 3 | 6 | 5.51 | .341 | 1.55 | 10.6 | 3.4 | 8.5 | 67.0 | 79 | 51 | 41 | 10 | 25 | 63 | 0 | 0 | 0 | 0 | 4 | 0 | 1 | 4.18 |
| SP | Robinson, J.Robinson, Jeff >> | 27 | 1988 | R | 31 | 11 | 11 | 2 | 5 | 5.02 | .339 | 1.53 | 9.5 | 4.3 | 6.7 | 75.1 | 79 | 42 | 42 | 9 | 36 | 56 | 0 | 0 | 0 | 0 | 4 | 1 | 4 | 4.55 |
| SP | Hiller, J.Hiller, John >> | 25 | 1968 | L | 25 | 8 | 8 | 0 | 1 | 3.45 | .277 | 1.15 | 6.4 | 4.1 | 4.4 | 31.1 | 22 | 14 | 12 | 4 | 14 | 15 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.06 |
| RP | Holton, T.Holton, Tyler >> | 28 | 2024 | L | 70 | 32 | 0 | 3 | 2 | 4.50 | .304 | 1.31 | 8.8 | 3.0 | 6.6 | 42.0 | 41 | 21 | 21 | 8 | 14 | 31 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 5.00 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 67 | 23 | 0 | 3 | 3 | 5.96 | .352 | 1.63 | 9.0 | 6.1 | 11.0 | 22.2 | 22 | 15 | 15 | 4 | 15 | 27 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.95 |
| RP | Saucier, K.Saucier, Kevin >> | 25 | 1981 | L | 43 | 17 | 0 | 2 | 2 | 5.66 | .361 | 1.69 | 9.9 | 5.9 | 4.5 | 20.2 | 22 | 13 | 13 | 2 | 13 | 10 | 0 | 1 | 1 | 0 | 0 | 0 | 2 | 5.25 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 44 | 11 | 0 | 1 | 0 | 1.72 | .161 | 0.57 | 3.0 | 2.4 | 5.4 | 15.2 | 5 | 3 | 3 | 2 | 4 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.33 |
| RP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 34 | 4 | 0 | 0 | 1 | 2.45 | .214 | 0.55 | 6.0 | 0.0 | 6.0 | 3.2 | 2 | 1 | 1 | 0 | 0 | 2 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.67 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 32 | 4 | 0 | 0 | 0 | 0.00 | .286 | 1.20 | 3.0 | 9.0 | 15.0 | 3.1 | 1 | 0 | 0 | 0 | 3 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.67 |