| SP | Cotton, J.Cotton, Jharel † >> | 24 | 2016 | R | 97 | 32 | 32 | 13 | 9 | 2.49 | .271 | 1.09 | 7.7 | 2.1 | 7.9 | 213.0 | 183 | 66 | 59 | 14 | 50 | 186 | 2 | 0 | 0 | 1 | 26 | 5 | 7 | 2.88 |
| SP | Straily, D.Straily, Dan >> | 27 | 2016 | R | 87 | 32 | 32 | 12 | 5 | 4.04 | .303 | 1.28 | 8.5 | 3.0 | 8.3 | 198.1 | 187 | 92 | 89 | 15 | 67 | 182 | 0 | 0 | 0 | 0 | 16 | 5 | 7 | 3.24 |
| SP | Manaea, S.Manaea, Sean # >> | 24 | 2016 | L | 79 | 31 | 31 | 9 | 10 | 5.05 | .334 | 1.45 | 10.1 | 2.9 | 8.2 | 173.0 | 195 | 105 | 97 | 25 | 56 | 157 | 0 | 0 | 0 | 0 | 12 | 9 | 7 | 4.19 |
| SP | Kazmir, S.Kazmir, Scott # >> | 32 | 2016 | L | 58 | 27 | 27 | 6 | 14 | 5.45 | .336 | 1.47 | 10.1 | 3.2 | 8.0 | 142.0 | 159 | 99 | 86 | 31 | 50 | 127 | 0 | 0 | 0 | 0 | 11 | 7 | 4 | 5.25 |
| SP | Gonzalez, G.Gonzalez, Gio >> | 31 | 2016 | L | 56 | 21 | 21 | 2 | 13 | 6.69 | .359 | 1.65 | 11.6 | 3.2 | 8.1 | 113.0 | 146 | 89 | 84 | 23 | 40 | 102 | 0 | 0 | 0 | 0 | 5 | 4 | 3 | 5.01 |
| RP | Doolittle, S.Doolittle, Sean # >> | 29 | 2016 | L | 84 | 99 | 0 | 4 | 4 | 4.68 | .336 | 1.50 | 10.7 | 2.8 | 9.5 | 67.1 | 80 | 37 | 35 | 5 | 21 | 71 | 0 | 0 | 3 | 0 | 0 | 1 | 4 | 2.84 |
| RP | Blevins, J.Blevins, Jerry >> | 33 | 2016 | L | 74 | 85 | 0 | 4 | 1 | 3.25 | .252 | 0.98 | 6.7 | 2.1 | 10.0 | 55.1 | 41 | 21 | 20 | 4 | 13 | 61 | 0 | 2 | 2 | 0 | 0 | 2 | 2 | 2.55 |
| RP | Casilla, S.Casilla, Santiago >> | 36 | 2016 | R | 72 | 86 | 0 | 4 | 4 | 5.55 | .328 | 1.37 | 9.0 | 3.3 | 9.3 | 60.0 | 60 | 41 | 37 | 9 | 22 | 62 | 0 | 0 | 4 | 0 | 0 | 6 | 5 | 4.28 |
| RP | Triggs, A.Triggs, Andrew >> | 27 | 2016 | R | 57 | 49 | 0 | 4 | 4 | 4.29 | .304 | 1.24 | 9.2 | 2.0 | 9.0 | 77.2 | 79 | 41 | 37 | 4 | 17 | 77 | 0 | 0 | 1 | 0 | 0 | 6 | 3 | 2.57 |
| SP | Graveman, K.Graveman, Kendall >> | 25 | 2016 | R | 49 | 17 | 0 | 3 | 1 | 5.71 | .330 | 1.46 | 10.1 | 3.1 | 9.5 | 58.1 | 65 | 38 | 37 | 11 | 20 | 61 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.45 |