| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 100 | 32 | 32 | 16 | 12 | 2.95 | .285 | 1.11 | 8.8 | 1.3 | 10.1 | 234.2 | 228 | 80 | 77 | 18 | 33 | 262 | 3 | 0 | 0 | 1 | 27 | 19 | 2 | 2.43 |
| SP | Estrada, M.Estrada, Marco >> | 33 | 2016 | R | 94 | 31 | 31 | 9 | 10 | 3.74 | .303 | 1.29 | 7.8 | 3.8 | 7.6 | 192.2 | 167 | 86 | 80 | 18 | 82 | 162 | 0 | 0 | 0 | 0 | 15 | 2 | 4 | 3.84 |
| SP | Odorizzi, J.Odorizzi, Jake # >> | 26 | 2016 | R | 84 | 28 | 27 | 8 | 12 | 4.65 | .341 | 1.51 | 9.4 | 4.3 | 7.9 | 141.1 | 147 | 80 | 73 | 15 | 67 | 123 | 0 | 0 | 0 | 0 | 10 | 5 | 3 | 4.17 |
| SP | De La Rosa, R.De La Rosa, Rubby # >> | 27 | 2016 | R | 83 | 27 | 21 | 8 | 5 | 5.03 | .322 | 1.41 | 9.1 | 3.7 | 9.5 | 91.1 | 92 | 53 | 51 | 10 | 37 | 96 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.57 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 100 | 89 | 0 | 5 | 2 | 1.88 | .224 | 0.85 | 6.1 | 1.6 | 12.2 | 105.1 | 71 | 24 | 22 | 6 | 19 | 142 | 0 | 7 | 1 | 0 | 0 | 1 | 1 | 1.61 |
| RP | Dayton, G.Dayton, Grant >> | 28 | 2016 | L | 100 | 97 | 0 | 5 | 1 | 1.29 | .247 | 0.97 | 5.3 | 3.4 | 9.6 | 97.1 | 57 | 17 | 14 | 2 | 37 | 103 | 0 | 7 | 0 | 0 | 0 | 2 | 0 | 2.35 |
| RP | Blanton, J.Blanton, Joe >> | 36 | 2016 | R | 91 | 76 | 0 | 4 | 3 | 3.43 | .286 | 1.17 | 7.6 | 3.0 | 7.9 | 65.2 | 55 | 25 | 25 | 5 | 22 | 57 | 0 | 6 | 2 | 0 | 0 | 2 | 2 | 3.35 |
| RP | Liberatore, A.Liberatore, Adam >> | 29 | 2016 | L | 76 | 83 | 0 | 2 | 1 | 0.72 | .260 | 1.05 | 6.1 | 3.4 | 10.6 | 75.0 | 51 | 12 | 6 | 1 | 28 | 88 | 0 | 6 | 2 | 0 | 0 | 0 | 4 | 1.95 |