| SP | Pomeranz, D.Pomeranz, Drew # >> | 27 | 2016 | L | 92 | 33 | 33 | 9 | 9 | 4.03 | .317 | 1.34 | 8.0 | 4.1 | 10.3 | 178.2 | 158 | 86 | 80 | 24 | 82 | 203 | 0 | 0 | 0 | 0 | 14 | 9 | 7 | 4.01 |
| SP | Greinke, Z.Greinke, Zack # >> | 33 | 2016 | R | 63 | 31 | 31 | 11 | 12 | 4.54 | .336 | 1.48 | 10.2 | 3.1 | 7.3 | 186.1 | 211 | 101 | 94 | 24 | 64 | 150 | 0 | 0 | 0 | 0 | 15 | 8 | 3 | 4.23 |
| SP | Anderson, T.Anderson, Tyler >> | 26 | 2016 | L | 58 | 27 | 27 | 7 | 11 | 4.63 | .332 | 1.48 | 10.3 | 3.1 | 8.2 | 159.1 | 182 | 85 | 82 | 30 | 54 | 145 | 1 | 0 | 0 | 1 | 11 | 2 | 1 | 4.69 |
| RP | Hochevar, L.Hochevar, Luke >> | 33 | 2016 | R | 82 | 85 | 0 | 6 | 7 | 3.69 | .265 | 1.05 | 7.1 | 2.4 | 10.0 | 114.2 | 90 | 51 | 47 | 9 | 30 | 127 | 0 | 0 | 8 | 0 | 0 | 4 | 7 | 2.69 |
| CL | Strahm, M.Strahm, Matt † >> | 24 | 2016 | L | 94 | 56 | 0 | 7 | 1 | 0.87 | .221 | 0.85 | 4.5 | 3.2 | 10.5 | 62.1 | 31 | 7 | 6 | 0 | 22 | 72 | 0 | 30 | 3 | 0 | 0 | 0 | 2 | 1.74 |
| RP | Jeffress, J.Jeffress, Jeremy >> | 28 | 2016 | R | 54 | 70 | 0 | 8 | 3 | 3.72 | .280 | 1.15 | 7.8 | 2.6 | 8.3 | 77.1 | 67 | 32 | 32 | 10 | 22 | 71 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.74 |
| SU | Herrera, K.Herrera, Kelvin >> | 26 | 2016 | R | 90 | 65 | 0 | 2 | 0 | 1.98 | .221 | 0.82 | 5.2 | 2.3 | 11.6 | 68.1 | 39 | 15 | 15 | 6 | 17 | 88 | 0 | 10 | 5 | 0 | 0 | 2 | 3 | 2.40 |
| RP | Soria, J.Soria, Joakim >> | 32 | 2016 | R | 31 | 52 | 0 | 4 | 3 | 3.95 | .302 | 1.30 | 10.3 | 1.5 | 10.8 | 54.2 | 62 | 27 | 24 | 7 | 9 | 65 | 0 | 1 | 0 | 0 | 0 | 0 | 2 | 2.78 |
| SP | Bradley, A.Bradley, Archie # >> | 23 | 2016 | R | 31 | 19 | 1 | 4 | 4 | 6.23 | .354 | 1.64 | 12.0 | 2.9 | 9.1 | 69.1 | 92 | 51 | 48 | 14 | 22 | 70 | 0 | 0 | 0 | 0 | 0 | 0 | 5 | 4.57 |