| SP | Scherzer, M.Scherzer, Max † >> | 32 | 2016 | R | 100 | 33 | 33 | 18 | 12 | 3.11 | .288 | 1.17 | 8.3 | 2.3 | 10.0 | 237.1 | 218 | 85 | 82 | 20 | 60 | 264 | 2 | 0 | 0 | 1 | 24 | 10 | 2 | 2.76 |
| SP | Arrieta, J.Arrieta, Jake >> | 30 | 2016 | R | 97 | 31 | 31 | 14 | 9 | 3.86 | .334 | 1.45 | 8.6 | 4.5 | 7.7 | 200.1 | 191 | 88 | 86 | 16 | 99 | 171 | 0 | 0 | 0 | 0 | 18 | 11 | 9 | 3.98 |
| SP | Miranda, A.Miranda, Ariel # >> | 27 | 2016 | L | 87 | 30 | 30 | 11 | 10 | 3.78 | .281 | 1.14 | 7.7 | 2.6 | 7.4 | 157.0 | 134 | 74 | 66 | 17 | 45 | 129 | 0 | 0 | 0 | 0 | 8 | 5 | 4 | 3.72 |
| SP | Tillman, C.Tillman, Chris # >> | 28 | 2016 | R | 72 | 29 | 29 | 11 | 10 | 4.29 | .314 | 1.34 | 8.4 | 3.7 | 7.1 | 170.0 | 158 | 87 | 81 | 19 | 69 | 134 | 0 | 0 | 0 | 0 | 15 | 6 | 5 | 4.20 |
| SP | Gonzalez, M.Gonzalez, Miguel # >> | 32 | 2016 | R | 66 | 21 | 21 | 7 | 6 | 4.75 | .327 | 1.43 | 9.5 | 3.4 | 6.8 | 119.1 | 126 | 66 | 63 | 14 | 45 | 90 | 0 | 0 | 0 | 0 | 10 | 3 | 3 | 4.23 |
| CL | Britton, Z.Britton, Zach † >> | 28 | 2016 | L | 98 | 52 | 0 | 2 | 2 | 3.24 | .289 | 1.20 | 8.1 | 2.7 | 11.9 | 50.0 | 45 | 18 | 18 | 1 | 15 | 66 | 0 | 42 | 4 | 0 | 0 | 1 | 3 | 1.58 |
| RP | Drake, O.Drake, Oliver >> | 29 | 2016 | R | 95 | 93 | 0 | 4 | 1 | 3.14 | .319 | 1.35 | 6.9 | 5.4 | 10.3 | 94.2 | 72 | 36 | 33 | 8 | 56 | 108 | 0 | 1 | 6 | 0 | 0 | 5 | 2 | 3.76 |
| RP | Uehara, K.Uehara, Koji >> | 41 | 2016 | R | 94 | 67 | 0 | 6 | 3 | 2.37 | .260 | 1.03 | 6.3 | 3.0 | 12.3 | 76.0 | 53 | 22 | 20 | 7 | 25 | 104 | 0 | 2 | 1 | 0 | 0 | 2 | 3 | 2.53 |
| RP | Givens, M.Givens, Mychal # >> | 26 | 2016 | R | 70 | 50 | 0 | 4 | 4 | 5.29 | .359 | 1.59 | 9.6 | 5.0 | 10.0 | 47.2 | 50 | 28 | 28 | 3 | 26 | 52 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 3.53 |
| RP | Johnson, J.Johnson, Jim >> | 33 | 2016 | R | 68 | 31 | 0 | 1 | 2 | 5.70 | .366 | 1.70 | 12.0 | 3.3 | 9.6 | 30.0 | 40 | 19 | 19 | 4 | 11 | 32 | 0 | 1 | 2 | 0 | 0 | 1 | 3 | 3.80 |