| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 98 | 32 | 32 | 9 | 17 | 3.79 | .297 | 1.23 | 8.2 | 2.9 | 7.8 | 185.0 | 168 | 80 | 78 | 17 | 60 | 161 | 1 | 0 | 0 | 1 | 20 | 7 | 2 | 3.54 |
| SP | Archer, C.Archer, Chris # >> | 27 | 2016 | R | 80 | 31 | 31 | 10 | 10 | 4.53 | .315 | 1.33 | 8.4 | 3.5 | 11.4 | 175.0 | 164 | 89 | 88 | 14 | 69 | 221 | 0 | 0 | 0 | 0 | 15 | 8 | 0 | 2.83 |
| SP | Samardzija, J.Samardzija, Jeff # >> | 31 | 2016 | R | 76 | 27 | 27 | 9 | 9 | 4.08 | .302 | 1.26 | 8.8 | 2.5 | 7.0 | 170.0 | 167 | 83 | 77 | 22 | 47 | 132 | 2 | 0 | 0 | 1 | 15 | 7 | 1 | 4.08 |
| SP | Stroman, M.Stroman, Marcus >> | 25 | 2016 | R | 58 | 22 | 21 | 12 | 4 | 3.89 | .330 | 1.46 | 9.9 | 3.3 | 7.8 | 136.2 | 150 | 60 | 59 | 11 | 50 | 118 | 0 | 0 | 0 | 0 | 13 | 2 | 3 | 3.46 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 100 | 62 | 0 | 6 | 2 | 2.00 | .253 | 0.99 | 5.8 | 3.2 | 10.9 | 76.2 | 49 | 18 | 17 | 3 | 27 | 92 | 0 | 7 | 1 | 0 | 0 | 2 | 6 | 2.24 |
| RP | Rondon, H.Rondon, Hector >> | 28 | 2016 | R | 87 | 75 | 0 | 4 | 4 | 2.47 | .296 | 1.24 | 7.7 | 3.5 | 10.3 | 91.0 | 78 | 25 | 25 | 4 | 35 | 104 | 0 | 4 | 5 | 0 | 0 | 2 | 6 | 2.51 |
| RP | Zastryzny, R.Zastryzny, Rob † >> | 24 | 2016 | L | 86 | 37 | 0 | 4 | 3 | 2.95 | .250 | 0.97 | 5.8 | 3.0 | 12.4 | 61.0 | 39 | 21 | 20 | 4 | 20 | 84 | 0 | 4 | 2 | 0 | 0 | 2 | 0 | 2.18 |
| RP | Grilli, J.Grilli, Jason † >> | 40 | 2016 | R | 73 | 55 | 0 | 9 | 3 | 2.30 | .267 | 1.07 | 4.5 | 5.1 | 10.3 | 70.1 | 35 | 18 | 18 | 3 | 40 | 80 | 0 | 9 | 4 | 0 | 0 | 2 | 1 | 3.07 |
| RP | Cedeno, X.Cedeno, Xavier >> | 29 | 2016 | L | 70 | 58 | 0 | 3 | 0 | 2.09 | .261 | 1.03 | 6.5 | 2.9 | 10.2 | 60.1 | 43 | 14 | 14 | 2 | 19 | 68 | 0 | 9 | 1 | 0 | 0 | 2 | 2 | 2.22 |
| SP | Conley, A.Conley, Adam >> | 26 | 2016 | R | 55 | 18 | 1 | 1 | 2 | 4.42 | .321 | 1.36 | 8.7 | 3.5 | 9.4 | 71.1 | 69 | 37 | 35 | 10 | 28 | 74 | 0 | 1 | 0 | 0 | 1 | 4 | 2 | 4.10 |