| SP | Strasburg, S.Strasburg, Stephen † >> | 27 | 2016 | R | 95 | 33 | 33 | 21 | 6 | 3.18 | .299 | 1.24 | 8.5 | 2.7 | 10.9 | 215.0 | 203 | 86 | 76 | 18 | 64 | 260 | 0 | 0 | 0 | 0 | 24 | 8 | 4 | 2.67 |
| SP | Iwakuma, H.Iwakuma, Hisashi # >> | 35 | 2016 | R | 47 | 30 | 30 | 9 | 13 | 4.65 | .321 | 1.37 | 9.8 | 2.5 | 8.0 | 149.0 | 162 | 84 | 77 | 26 | 42 | 132 | 0 | 0 | 0 | 0 | 8 | 7 | 1 | 4.48 |
| SP | Skaggs, T.Skaggs, Tyler # >> | 24 | 2016 | L | 40 | 26 | 18 | 0 | 5 | 5.97 | .362 | 1.67 | 10.9 | 4.3 | 11.4 | 72.1 | 87 | 50 | 48 | 18 | 34 | 91 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5.22 |
| CL | Chamberlain, J.Chamberlain, Joba >> | 31 | 2016 | R | 83 | 68 | 0 | 2 | 5 | 4.10 | .344 | 1.54 | 7.4 | 6.6 | 9.0 | 63.2 | 52 | 32 | 29 | 8 | 46 | 63 | 0 | 32 | 5 | 0 | 0 | 2 | 3 | 4.94 |
| RP | Glover, K.Glover, Koda >> | 23 | 2016 | R | 75 | 85 | 0 | 11 | 2 | 3.03 | .304 | 1.27 | 7.9 | 3.5 | 8.0 | 104.0 | 91 | 43 | 35 | 8 | 41 | 93 | 0 | 3 | 2 | 0 | 0 | 4 | 3 | 3.51 |
| RP | Treinen, B.Treinen, Blake >> | 28 | 2016 | R | 72 | 72 | 0 | 8 | 3 | 2.00 | .277 | 1.12 | 5.8 | 4.3 | 8.4 | 81.0 | 52 | 18 | 18 | 4 | 39 | 76 | 0 | 3 | 3 | 0 | 0 | 2 | 3 | 3.28 |
| RP | Rivero, F.Rivero, Felipe >> | 24 | 2016 | L | 65 | 98 | 0 | 2 | 2 | 3.90 | .299 | 1.24 | 7.3 | 3.9 | 9.6 | 90.0 | 73 | 40 | 39 | 9 | 39 | 96 | 0 | 0 | 1 | 0 | 0 | 3 | 3 | 3.57 |
| RP | Warren, A.Warren, Adam >> | 28 | 2016 | R | 48 | 69 | 0 | 5 | 2 | 2.67 | .296 | 1.17 | 7.4 | 3.3 | 10.2 | 77.2 | 63 | 24 | 23 | 5 | 28 | 87 | 0 | 0 | 1 | 0 | 0 | 7 | 4 | 2.95 |