| SP | Lester, J.Lester, Jon † >> | 32 | 2016 | L | 98 | 33 | 33 | 19 | 5 | 2.37 | .251 | 0.97 | 6.6 | 2.1 | 8.2 | 239.2 | 175 | 64 | 63 | 11 | 57 | 218 | 0 | 0 | 0 | 0 | 28 | 9 | 5 | 2.60 |
| SP | Wright, S.Wright, Steven # >> | 31 | 2016 | R | 75 | 32 | 32 | 13 | 11 | 4.82 | .312 | 1.31 | 8.4 | 3.3 | 8.2 | 207.1 | 194 | 111 | 111 | 24 | 77 | 188 | 2 | 0 | 0 | 0 | 17 | 11 | 20 | 3.97 |
| SP | Rodriguez, E.Rodriguez, Eduardo >> | 23 | 2016 | L | 71 | 30 | 30 | 16 | 4 | 3.98 | .308 | 1.29 | 8.4 | 3.2 | 6.9 | 174.0 | 163 | 80 | 77 | 22 | 61 | 133 | 0 | 0 | 0 | 0 | 11 | 8 | 0 | 4.30 |
| SP | Finnegan, B.Finnegan, Brandon # >> | 23 | 2016 | L | 64 | 27 | 27 | 7 | 8 | 4.73 | .319 | 1.38 | 8.6 | 3.8 | 8.1 | 150.1 | 144 | 79 | 79 | 19 | 63 | 135 | 0 | 0 | 0 | 0 | 11 | 4 | 5 | 4.19 |
| SP | Buchholz, C.Buchholz, Clay # >> | 32 | 2016 | R | 56 | 24 | 24 | 3 | 6 | 4.16 | .307 | 1.33 | 8.4 | 3.7 | 7.1 | 101.2 | 94 | 48 | 47 | 16 | 41 | 80 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.69 |
| RP | Torres, C.Torres, Carlos >> | 33 | 2016 | R | 78 | 87 | 0 | 3 | 3 | 2.78 | .283 | 1.15 | 7.3 | 3.0 | 8.2 | 110.0 | 89 | 34 | 34 | 11 | 37 | 100 | 0 | 4 | 5 | 0 | 0 | 4 | 2 | 3.60 |
| RP | McGowan, D.McGowan, Dustin >> | 34 | 2016 | R | 77 | 86 | 0 | 8 | 4 | 3.62 | .285 | 1.17 | 7.1 | 3.4 | 6.4 | 92.0 | 73 | 38 | 37 | 11 | 35 | 65 | 0 | 11 | 5 | 0 | 0 | 2 | 2 | 4.35 |
| RP | Wilson, A.Wilson, Alex † >> | 29 | 2016 | R | 60 | 55 | 0 | 4 | 4 | 2.77 | .250 | 0.94 | 6.2 | 2.3 | 8.0 | 52.0 | 36 | 16 | 16 | 4 | 13 | 46 | 0 | 9 | 0 | 0 | 0 | 3 | 0 | 3.15 |
| SP | Liriano, F.Liriano, Francisco >> | 33 | 2016 | L | 50 | 28 | 0 | 11 | 6 | 4.29 | .328 | 1.42 | 7.8 | 5.0 | 10.3 | 113.1 | 98 | 57 | 54 | 7 | 63 | 129 | 0 | 0 | 0 | 0 | 0 | 5 | 2 | 3.33 |