| SP | Perez, O.Perez, Oliver >> | 27 | 2004 | L | 96 | 33 | 33 | 16 | 12 | 3.46 | .269 | 1.05 | 6.4 | 3.1 | 9.2 | 228.2 | 162 | 91 | 88 | 35 | 79 | 234 | 7 | 0 | 0 | 2 | 20 | 11 | 2 | 4.13 |
| SP | Peavy, J.Peavy, Jake † >> | 27 | 2005 | R | 96 | 33 | 33 | 20 | 6 | 2.57 | .269 | 1.07 | 6.9 | 2.8 | 9.7 | 256.0 | 196 | 73 | 73 | 24 | 79 | 277 | 9 | 0 | 0 | 3 | 26 | 7 | 4 | 3.06 |
| SP | Wright, J.Wright, Jaret # >> | 33 | 1997 | R | 75 | 32 | 32 | 10 | 14 | 5.10 | .306 | 1.31 | 9.4 | 2.4 | 7.1 | 199.1 | 207 | 116 | 113 | 41 | 54 | 157 | 1 | 0 | 0 | 0 | 14 | 3 | 1 | 4.96 |
| RP | Walker, K.Walker, Kevin >> | 32 | 2000 | L | 97 | 75 | 0 | 7 | 3 | 2.19 | .241 | 0.94 | 6.2 | 2.3 | 9.5 | 98.2 | 68 | 29 | 24 | 7 | 25 | 103 | 0 | 3 | 3 | 0 | 0 | 1 | 1 | 2.62 |
| RP | Aquino, G.Aquino, Greg >> | 30 | 2004 | R | 83 | 41 | 0 | 1 | 1 | 4.01 | .326 | 1.43 | 9.0 | 4.1 | 7.7 | 42.2 | 42 | 24 | 19 | 6 | 19 | 36 | 0 | 1 | 1 | 0 | 0 | 1 | 3 | 4.57 |
| RP | Hensley, C.Hensley, Clay >> | 29 | 2005 | R | 82 | 26 | 0 | 2 | 0 | 4.41 | .320 | 1.38 | 9.8 | 2.9 | 5.6 | 34.2 | 37 | 17 | 17 | 6 | 11 | 21 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 5.12 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 36 | 1999 | R | 78 | 20 | 0 | 0 | 1 | 4.84 | .309 | 1.30 | 7.4 | 4.5 | 7.8 | 22.1 | 18 | 12 | 12 | 5 | 11 | 19 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 5.86 |
| SP | Serafini, D.Serafini, Dan >> | 34 | 1997 | L | 74 | 12 | 0 | 4 | 0 | 4.29 | .283 | 1.18 | 8.8 | 1.9 | 5.6 | 56.2 | 55 | 29 | 27 | 5 | 12 | 35 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.55 |
| CL | Meredith, C.Meredith, Cla >> | 25 | 2006 | R | 97 | 63 | 0 | 3 | 15 | 4.41 | .285 | 1.16 | 8.3 | 2.2 | 5.0 | 65.1 | 60 | 35 | 32 | 12 | 16 | 36 | 0 | 35 | 5 | 0 | 0 | 2 | 0 | 5.12 |
| SU | Fikac, J.Fikac, Jeremy >> | 33 | 2001 | R | 96 | 45 | 0 | 2 | 0 | 2.19 | .225 | 0.81 | 5.9 | 1.5 | 6.6 | 49.1 | 32 | 13 | 12 | 7 | 8 | 36 | 0 | 4 | 5 | 0 | 0 | 3 | 0 | 4.06 |