| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 88 | 32 | 32 | 13 | 9 | 2.77 | .266 | 1.07 | 6.7 | 2.9 | 9.9 | 198.0 | 148 | 64 | 61 | 15 | 63 | 218 | 0 | 0 | 0 | 0 | 23 | 4 | 3 | 2.80 |
| SP | Zambrano, C.Zambrano, Carlos # >> | 27 | 2005 | R | 86 | 32 | 32 | 13 | 14 | 4.75 | .339 | 1.52 | 9.0 | 4.7 | 7.3 | 183.2 | 183 | 107 | 97 | 22 | 96 | 149 | 0 | 0 | 0 | 0 | 17 | 4 | 6 | 4.57 |
| SP | Willis, D.Willis, Dontrelle # >> | 26 | 2003 | L | 80 | 31 | 31 | 8 | 13 | 5.84 | .323 | 1.40 | 9.6 | 3.0 | 7.5 | 163.1 | 174 | 113 | 106 | 31 | 55 | 135 | 9 | 0 | 0 | 3 | 8 | 5 | 6 | 4.92 |
| RP | Wellemeyer, T.Wellemeyer, Todd >> | 30 | 2003 | R | 64 | 41 | 0 | 3 | 1 | 4.41 | .340 | 1.53 | 8.6 | 5.3 | 9.1 | 65.1 | 62 | 34 | 32 | 10 | 38 | 66 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 4.77 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2007 | R | 93 | 70 | 0 | 3 | 7 | 3.14 | .302 | 1.26 | 6.5 | 4.9 | 9.0 | 94.2 | 68 | 37 | 33 | 10 | 51 | 94 | 0 | 5 | 6 | 0 | 0 | 4 | 7 | 4.14 |
| RP | Farnsworth, K.Farnsworth, Kyle >> | 32 | 2001 | R | 94 | 75 | 0 | 5 | 4 | 2.81 | .289 | 1.20 | 8.1 | 2.7 | 9.9 | 102.2 | 92 | 36 | 32 | 9 | 31 | 112 | 0 | 11 | 2 | 0 | 0 | 2 | 5 | 2.92 |
| RP | Corpas, M.Corpas, Manuel >> | 26 | 2007 | R | 65 | 29 | 0 | 2 | 0 | 2.92 | .284 | 1.16 | 8.5 | 1.9 | 7.3 | 37.0 | 35 | 13 | 12 | 5 | 8 | 30 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 3.86 |
| RP | Linebrink, S.Linebrink, Scott >> | 32 | 2004 | R | 71 | 35 | 0 | 2 | 3 | 6.13 | .339 | 1.51 | 9.2 | 4.6 | 8.3 | 39.2 | 40 | 27 | 27 | 8 | 20 | 36 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 5.44 |
| RP | Aardsma, D.Aardsma, David # >> | 27 | 2006 | R | 80 | 44 | 0 | 4 | 5 | 5.10 | .318 | 1.38 | 9.8 | 2.7 | 9.0 | 60.0 | 65 | 41 | 34 | 12 | 18 | 60 | 0 | 5 | 3 | 0 | 0 | 1 | 0 | 4.55 |