| SP | Jimenez, U.Jimenez, Ubaldo # >> | 26 | 2010 | R | 26 | 24 | 24 | 5 | 13 | 4.87 | .334 | 1.48 | 9.1 | 4.3 | 7.5 | 157.0 | 158 | 87 | 85 | 19 | 75 | 130 | 0 | 0 | 0 | 0 | 10 | 3 | 6 | 4.41 |
| SP | Marquez, G.Marquez, German # >> | 23 | 2018 | R | 12 | 23 | 23 | 13 | 7 | 4.55 | .301 | 1.28 | 8.5 | 3.0 | 9.0 | 142.1 | 134 | 73 | 72 | 18 | 48 | 142 | 0 | 0 | 0 | 0 | 13 | 2 | 1 | 3.70 |
| SP | Gomber, A.Gomber, Austin >> | 27 | 2021 | L | 9 | 21 | 21 | 7 | 5 | 4.79 | .317 | 1.37 | 8.7 | 3.7 | 6.8 | 107.0 | 103 | 58 | 57 | 17 | 44 | 81 | 0 | 0 | 0 | 0 | 3 | 2 | 2 | 4.84 |
| SP | Chacin, J.Chacin, Jhoulys # >> | 22 | 2010 | R | 11 | 17 | 16 | 4 | 7 | 5.49 | .346 | 1.52 | 10.0 | 3.7 | 7.6 | 82.0 | 91 | 51 | 50 | 19 | 34 | 69 | 0 | 0 | 0 | 0 | 4 | 5 | 2 | 5.76 |
| RP | Buchholz, T.Buchholz, Taylor >> | 27 | 2008 | R | 25 | 71 | 0 | 3 | 0 | 3.89 | .306 | 1.31 | 8.4 | 3.3 | 5.1 | 81.0 | 76 | 35 | 35 | 14 | 30 | 46 | 0 | 0 | 0 | 0 | 0 | 1 | 5 | 5.26 |
| RP | Miller, J.Miller, Justin >> | 28 | 2015 | R | 33 | 61 | 0 | 6 | 2 | 3.84 | .292 | 1.22 | 7.3 | 3.7 | 9.3 | 68.0 | 55 | 31 | 29 | 10 | 28 | 70 | 0 | 0 | 2 | 0 | 0 | 1 | 2 | 4.13 |
| RP | Ottavino, A.Ottavino, Adam >> | 32 | 2018 | R | 48 | 31 | 0 | 4 | 1 | 3.99 | .296 | 1.26 | 7.4 | 4.0 | 9.9 | 29.1 | 24 | 15 | 13 | 5 | 13 | 32 | 0 | 1 | 1 | 0 | 0 | 0 | 3 | 4.38 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 48 | 28 | 0 | 0 | 1 | 2.67 | .279 | 1.10 | 8.5 | 1.6 | 9.8 | 33.2 | 31 | 10 | 10 | 2 | 6 | 36 | 0 | 0 | 1 | 0 | 0 | 2 | 1 | 2.33 |
| CL | Street, H.Street, Huston >> | 26 | 2009 | R | 38 | 46 | 0 | 2 | 2 | 2.72 | .331 | 1.46 | 8.1 | 5.3 | 8.5 | 39.2 | 35 | 13 | 12 | 6 | 23 | 37 | 0 | 32 | 5 | 0 | 0 | 1 | 0 | 4.95 |