| SP | Verlander, J.Verlander, Justin # >> | 28 | 2011 | R | 89 | 36 | 36 | 14 | 17 | 4.57 | .314 | 1.35 | 8.9 | 3.3 | 8.0 | 267.2 | 264 | 146 | 136 | 46 | 98 | 236 | 4 | 0 | 0 | 1 | 18 | 5 | 8 | 4.63 |
| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 91 | 35 | 35 | 14 | 12 | 3.50 | .294 | 1.23 | 8.8 | 2.3 | 9.0 | 239.0 | 233 | 101 | 93 | 32 | 61 | 240 | 0 | 0 | 0 | 0 | 21 | 4 | 1 | 3.55 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 81 | 33 | 33 | 11 | 19 | 4.99 | .324 | 1.41 | 9.4 | 3.3 | 6.7 | 240.0 | 250 | 135 | 133 | 32 | 88 | 179 | 11 | 0 | 0 | 3 | 13 | 7 | 8 | 4.43 |
| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 75 | 31 | 31 | 10 | 13 | 4.25 | .320 | 1.38 | 9.1 | 3.3 | 8.4 | 209.2 | 212 | 107 | 99 | 32 | 77 | 194 | 1 | 0 | 0 | 1 | 13 | 7 | 2 | 4.34 |
| SP | Lolich, M.Lolich, Mickey >> | 28 | 1968 | L | 21 | 27 | 27 | 9 | 10 | 3.96 | .306 | 1.27 | 8.0 | 3.5 | 6.5 | 163.2 | 145 | 77 | 72 | 20 | 63 | 117 | 0 | 0 | 0 | 0 | 15 | 8 | 4 | 4.47 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 70 | 91 | 0 | 3 | 8 | 3.58 | .324 | 1.40 | 8.5 | 4.2 | 9.0 | 105.2 | 99 | 44 | 42 | 11 | 49 | 105 | 0 | 6 | 6 | 0 | 0 | 4 | 0 | 3.88 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 58 | 77 | 0 | 4 | 6 | 3.42 | .306 | 1.30 | 6.7 | 5.1 | 9.1 | 81.2 | 60 | 35 | 31 | 9 | 46 | 82 | 0 | 16 | 2 | 0 | 0 | 2 | 5 | 4.20 |
| RP | McMahon, D.McMahon, Don # >> | 38 | 1968 | R | 49 | 47 | 0 | 1 | 5 | 4.74 | .312 | 1.34 | 9.0 | 3.1 | 7.2 | 49.1 | 49 | 26 | 26 | 11 | 17 | 39 | 0 | 12 | 0 | 0 | 0 | 1 | 2 | 5.43 |
| RP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 39 | 18 | 0 | 3 | 1 | 1.64 | .275 | 1.05 | 6.5 | 2.9 | 6.5 | 22.0 | 16 | 6 | 4 | 4 | 7 | 16 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 5.14 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 40 | 4 | 0 | 0 | 1 | 8.31 | .381 | 1.85 | 9.0 | 9.0 | 9.0 | 4.1 | 4 | 4 | 4 | 1 | 4 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.25 |
| RP | Melton, T.Melton, Troy >> | 24 | 2025 | R | 19 | 8 | 0 | 0 | 0 | 0.00 | .233 | 0.91 | 6.5 | 1.6 | 5.7 | 11.0 | 8 | 0 | 0 | 0 | 2 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.27 |