| SP | Verlander, J.Verlander, Justin >> | 28 | 2011 | R | 89 | 36 | 36 | 17 | 14 | 4.12 | .311 | 1.34 | 9.2 | 3.0 | 7.6 | 231.1 | 235 | 110 | 106 | 16 | 76 | 194 | 4 | 0 | 0 | 2 | 22 | 2 | 2 | 3.23 |
| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 89 | 34 | 34 | 13 | 12 | 3.33 | .289 | 1.19 | 8.5 | 2.2 | 9.3 | 216.1 | 205 | 83 | 80 | 23 | 53 | 222 | 0 | 0 | 0 | 0 | 26 | 6 | 6 | 3.15 |
| SP | Scherzer, M.Scherzer, Max # >> | 29 | 2013 | R | 74 | 34 | 34 | 9 | 13 | 5.27 | .325 | 1.43 | 9.1 | 3.7 | 9.5 | 181.0 | 183 | 106 | 106 | 23 | 75 | 192 | 3 | 0 | 0 | 0 | 13 | 4 | 5 | 3.84 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 69 | 31 | 31 | 7 | 10 | 4.71 | .313 | 1.36 | 9.2 | 3.0 | 9.3 | 164.1 | 168 | 87 | 86 | 19 | 55 | 170 | 0 | 0 | 0 | 0 | 13 | 2 | 3 | 3.48 |
| SP | Robinson, J.Robinson, Jeff # >> | 27 | 1988 | R | 27 | 27 | 23 | 3 | 8 | 6.00 | .355 | 1.63 | 10.0 | 4.7 | 6.1 | 126.0 | 140 | 90 | 84 | 20 | 66 | 86 | 2 | 0 | 0 | 0 | 6 | 2 | 4 | 5.32 |
| RP | McMahon, D.McMahon, Don >> | 38 | 1968 | R | 38 | 75 | 0 | 5 | 8 | 4.13 | .322 | 1.42 | 8.6 | 4.2 | 6.7 | 89.1 | 85 | 43 | 41 | 14 | 42 | 66 | 0 | 6 | 4 | 0 | 0 | 0 | 6 | 4.98 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 62 | 83 | 0 | 3 | 5 | 3.70 | .306 | 1.32 | 7.7 | 4.2 | 8.8 | 92.1 | 79 | 38 | 38 | 12 | 43 | 90 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 4.14 |
| RP | Hurter, B.Hurter, Brant >> | 25 | 2024 | L | 25 | 70 | 0 | 8 | 2 | 3.56 | .306 | 1.27 | 8.6 | 2.9 | 6.4 | 83.1 | 79 | 35 | 33 | 10 | 27 | 59 | 0 | 12 | 1 | 0 | 0 | 4 | 0 | 4.27 |
| SU | Alburquerque, A.Alburquerque, Al >> | 25 | 2011 | R | 42 | 45 | 0 | 2 | 2 | 5.65 | .328 | 1.42 | 7.3 | 5.4 | 11.1 | 43.0 | 35 | 27 | 27 | 5 | 26 | 53 | 0 | 4 | 3 | 0 | 0 | 2 | 3 | 4.00 |
| CL | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 29 | 41 | 0 | 1 | 2 | 2.80 | .278 | 1.13 | 5.6 | 4.6 | 9.0 | 45.0 | 28 | 15 | 14 | 4 | 23 | 45 | 0 | 8 | 1 | 0 | 0 | 1 | 3 | 3.76 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 52 | 79 | 0 | 3 | 8 | 4.70 | .315 | 1.36 | 7.7 | 4.6 | 10.3 | 69.0 | 59 | 38 | 36 | 6 | 35 | 79 | 0 | 7 | 2 | 0 | 0 | 1 | 5 | 3.41 |
| SP | Lolich, M.Lolich, Mickey >> | 28 | 1968 | L | 16 | 26 | 4 | 4 | 3 | 5.96 | .354 | 1.63 | 11.2 | 3.5 | 5.8 | 99.2 | 123 | 66 | 66 | 14 | 39 | 64 | 0 | 0 | 1 | 0 | 0 | 2 | 4 | 4.79 |