| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 96 | 35 | 35 | 19 | 7 | 3.83 | .297 | 1.26 | 7.6 | 3.7 | 7.5 | 242.0 | 205 | 105 | 103 | 22 | 100 | 201 | 4 | 0 | 0 | 3 | 22 | 2 | 8 | 3.79 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 63 | 35 | 35 | 8 | 19 | 5.74 | .352 | 1.60 | 11.1 | 3.3 | 6.3 | 196.0 | 241 | 131 | 125 | 36 | 72 | 138 | 1 | 0 | 0 | 0 | 14 | 6 | 4 | 5.17 |
| SP | Eckersley, D.Eckersley, Dennis # >> | 31 | 1985 | R | 42 | 35 | 35 | 11 | 16 | 4.89 | .306 | 1.28 | 9.2 | 2.3 | 5.7 | 231.2 | 237 | 128 | 126 | 35 | 60 | 146 | 4 | 0 | 0 | 1 | 17 | 9 | 0 | 4.60 |
| SP | Hammel, J.Hammel, Jason >> | 32 | 2014 | R | 33 | 31 | 31 | 8 | 21 | 5.10 | .336 | 1.51 | 10.0 | 3.6 | 6.5 | 190.2 | 211 | 113 | 108 | 28 | 77 | 137 | 0 | 0 | 0 | 0 | 12 | 1 | 2 | 4.71 |
| SP | Imanaga, S.Imanaga, Shota # >> | 31 | 2025 | L | 40 | 26 | 26 | 8 | 12 | 4.68 | .323 | 1.41 | 9.3 | 3.4 | 5.0 | 148.0 | 153 | 83 | 77 | 27 | 56 | 83 | 0 | 0 | 0 | 0 | 14 | 3 | 2 | 5.45 |
| RP | Edwards, C.Edwards, Carl >> | 24 | 2016 | R | 92 | 100 | 0 | 6 | 2 | 2.55 | .273 | 1.12 | 5.0 | 5.0 | 9.1 | 109.1 | 61 | 32 | 31 | 6 | 61 | 110 | 0 | 1 | 2 | 0 | 0 | 1 | 8 | 3.40 |
| CL | Kimbrel, C.Kimbrel, Craig >> | 33 | 2021 | R | 100 | 56 | 0 | 4 | 7 | 2.78 | .283 | 1.15 | 6.2 | 4.1 | 9.8 | 55.0 | 38 | 18 | 17 | 2 | 25 | 60 | 0 | 34 | 1 | 0 | 0 | 2 | 1 | 2.76 |
| RP | Tepera, R.Tepera, Ryan >> | 33 | 2021 | R | 85 | 73 | 0 | 4 | 1 | 2.12 | .265 | 1.07 | 6.0 | 3.6 | 10.2 | 85.0 | 57 | 20 | 20 | 6 | 34 | 96 | 0 | 1 | 2 | 0 | 0 | 1 | 2 | 2.89 |
| RP | Chavez, J.Chavez, Jesse >> | 35 | 2018 | R | 60 | 48 | 0 | 1 | 3 | 3.98 | .285 | 1.18 | 8.7 | 2.0 | 10.5 | 54.1 | 52 | 24 | 24 | 3 | 12 | 63 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 2.11 |
| RP | Miller, T.Miller, Tyson >> | 28 | 2024 | R | 59 | 32 | 0 | 1 | 2 | 3.82 | .266 | 1.04 | 7.8 | 1.7 | 5.1 | 37.2 | 32 | 16 | 16 | 4 | 7 | 21 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.00 |
| RP | Thielbar, C.Thielbar, Caleb >> | 38 | 2025 | L | 41 | 97 | 0 | 0 | 1 | 4.52 | .334 | 1.51 | 10.7 | 3.0 | 8.0 | 63.2 | 75 | 33 | 32 | 8 | 21 | 56 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 3.87 |