| SP | Scherzer, M.Scherzer, Max # >> | 37 | 2021 | R | 99 | 35 | 35 | 15 | 9 | 3.92 | .289 | 1.19 | 7.9 | 2.9 | 9.0 | 222.2 | 195 | 103 | 97 | 20 | 71 | 222 | 0 | 0 | 0 | 0 | 20 | 5 | 0 | 3.20 |
| SP | Martinez, P.Martinez, Pedro >> | 26 | 1997 | R | 93 | 35 | 35 | 15 | 14 | 3.45 | .280 | 1.14 | 7.3 | 3.1 | 9.8 | 268.2 | 216 | 105 | 103 | 30 | 91 | 291 | 12 | 0 | 0 | 2 | 22 | 7 | 3 | 3.38 |
| SP | Perez, P.Perez, Pascual >> | 31 | 1988 | R | 76 | 33 | 33 | 17 | 9 | 4.08 | .291 | 1.19 | 7.7 | 2.9 | 5.7 | 229.1 | 197 | 115 | 104 | 32 | 75 | 145 | 2 | 0 | 0 | 0 | 17 | 10 | 2 | 4.66 |
| SP | Strasburg, S.Strasburg, Stephen # >> | 24 | 2013 | R | 45 | 32 | 32 | 11 | 13 | 5.67 | .319 | 1.40 | 9.3 | 3.3 | 9.1 | 168.1 | 174 | 108 | 106 | 21 | 62 | 169 | 1 | 0 | 0 | 1 | 12 | 1 | 4 | 3.74 |
| SP | Martinez, D.Martinez, Dennis >> | 37 | 1992 | R | 41 | 28 | 26 | 7 | 13 | 5.04 | .325 | 1.43 | 10.1 | 2.8 | 5.6 | 160.2 | 180 | 92 | 90 | 27 | 49 | 100 | 4 | 0 | 0 | 0 | 11 | 3 | 2 | 4.92 |
| RP | Reardon, J.Reardon, Jeff >> | 26 | 1981 | R | 87 | 94 | 0 | 8 | 3 | 3.26 | .274 | 1.13 | 6.7 | 3.5 | 5.7 | 138.0 | 103 | 52 | 50 | 15 | 53 | 87 | 0 | 1 | 4 | 0 | 0 | 0 | 3 | 4.30 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 69 | 66 | 0 | 4 | 3 | 3.36 | .256 | 1.02 | 6.9 | 2.3 | 8.2 | 69.2 | 53 | 26 | 26 | 9 | 18 | 63 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.70 |
| RP | Hudson, D.Hudson, Daniel >> | 34 | 2021 | R | 42 | 40 | 0 | 0 | 2 | 3.45 | .277 | 1.06 | 6.1 | 3.5 | 11.0 | 44.1 | 30 | 17 | 17 | 3 | 17 | 54 | 0 | 3 | 0 | 0 | 0 | 4 | 0 | 2.86 |
| RP | Roark, T.Roark, Tanner >> | 26 | 2013 | R | 30 | 34 | 0 | 4 | 0 | 2.69 | .272 | 1.12 | 7.7 | 2.4 | 6.6 | 70.1 | 60 | 22 | 21 | 5 | 19 | 51 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.29 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 76 | 0 | 6 | 8 | 3.42 | .280 | 1.14 | 8.6 | 1.7 | 8.9 | 76.1 | 73 | 29 | 29 | 8 | 14 | 75 | 0 | 40 | 5 | 0 | 0 | 2 | 5 | 3.03 |