| SP | Cahill, T.Cahill, Trevor # >> | 22 | 2010 | R | 90 | 8 | 8 | 4 | 3 | 3.93 | .335 | 1.42 | 10.0 | 2.8 | 5.9 | 55.0 | 61 | 28 | 24 | 4 | 17 | 36 | 0 | 0 | 0 | 0 | 4 | 5 | 1 | 3.84 |
| SP | Cramer, B.Cramer, Bobby >> | 30 | 2010 | L | 85 | 7 | 7 | 2 | 3 | 3.83 | .257 | 1.04 | 6.6 | 2.8 | 5.6 | 42.1 | 31 | 20 | 18 | 2 | 13 | 26 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 3.31 |
| SP | Braden, D.Braden, Dallas >> | 27 | 2010 | L | 78 | 4 | 4 | 2 | 0 | 4.00 | .319 | 1.41 | 10.0 | 2.7 | 9.3 | 27.0 | 30 | 14 | 12 | 1 | 8 | 28 | 1 | 0 | 0 | 0 | 2 | 0 | 1 | 2.30 |
| RP | Bailey, A.Bailey, Andrew >> | 26 | 2010 | R | 94 | 21 | 0 | 1 | 1 | 3.24 | .279 | 1.16 | 7.6 | 2.9 | 9.0 | 25.0 | 21 | 9 | 9 | 1 | 8 | 25 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 2.48 |
| RP | Casilla, S.Casilla, Santiago >> | 30 | 2010 | R | 83 | 16 | 0 | 2 | 0 | 1.59 | .292 | 1.18 | 4.8 | 5.8 | 8.5 | 17.0 | 9 | 3 | 3 | 1 | 11 | 16 | 0 | 0 | 0 | 0 | 0 | 1 | 4 | 4.00 |
| RP | Rodriguez, H.Rodriguez, Henry >> | 23 | 2010 | L | 57 | 10 | 0 | 0 | 1 | 7.15 | .370 | 1.76 | 6.5 | 9.8 | 10.6 | 11.1 | 8 | 9 | 9 | 0 | 12 | 13 | 0 | 0 | 3 | 0 | 0 | 0 | 2 | 3.91 |
| RP | Ziegler, B.Ziegler, Brad >> | 31 | 2010 | R | 55 | 11 | 0 | 0 | 0 | 1.50 | .265 | 1.08 | 5.3 | 4.5 | 5.3 | 12.0 | 7 | 2 | 2 | 1 | 6 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.42 |
| CL | Street, H.Street, Huston >> | 27 | 2010 | R | 84 | 10 | 0 | 0 | 1 | 1.42 | .240 | 0.95 | 6.8 | 2.3 | 11.3 | 12.2 | 9 | 2 | 2 | 0 | 3 | 15 | 0 | 5 | 0 | 0 | 0 | 0 | 0 | 1.25 |
| SP | Gonzalez, G.Gonzalez, Gio >> | 25 | 2010 | L | 75 | 3 | 0 | 0 | 0 | 4.32 | .351 | 1.56 | 9.6 | 5.1 | 6.2 | 16.2 | 17 | 11 | 8 | 2 | 9 | 11 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.13 |
| SP | Anderson, B.Anderson, Brett >> | 22 | 2010 | L | 71 | 3 | 0 | 1 | 2 | 6.23 | .278 | 1.15 | 11.3 | 0.0 | 6.8 | 4.1 | 5 | 3 | 3 | 1 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.75 |