| SP | Clemens, R.Clemens, Roger # >> | 44 | 2006 | R | 100 | 11 | 11 | 1 | 8 | 5.58 | .333 | 1.44 | 8.8 | 4.1 | 7.2 | 50.0 | 49 | 35 | 31 | 5 | 23 | 40 | 0 | 0 | 0 | 0 | 3 | 3 | 2 | 4.26 |
| RP | Coffey, T.Coffey, Todd >> | 26 | 2006 | R | 46 | 26 | 0 | 1 | 1 | 4.59 | .342 | 1.53 | 8.5 | 5.5 | 7.4 | 33.1 | 31 | 19 | 17 | 5 | 20 | 27 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 5.24 |
| RP | Belisle, M.Belisle, Matt >> | 26 | 2006 | R | 34 | 21 | 0 | 0 | 0 | 3.03 | .219 | 0.84 | 5.9 | 1.9 | 4.3 | 29.2 | 19 | 10 | 10 | 3 | 6 | 14 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.00 |
| RP | Delcarmen, M.Delcarmen, Manny >> | 24 | 2006 | R | 23 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SU | Carrasco, H.Carrasco, Hector >> | 37 | 2006 | R | 77 | 14 | 0 | 1 | 0 | 4.98 | .330 | 1.43 | 10.7 | 2.6 | 6.9 | 21.2 | 25 | 12 | 12 | 3 | 6 | 16 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 4.33 |
| CL | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 99 | 13 | 0 | 2 | 0 | 0.61 | .200 | 0.75 | 5.1 | 1.9 | 12.2 | 14.2 | 8 | 1 | 1 | 1 | 3 | 19 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 1.86 |
| RP | Rivera, S.Rivera, Saul >> | 29 | 2006 | R | 43 | 14 | 0 | 1 | 0 | 3.52 | .403 | 1.96 | 12.0 | 6.0 | 9.0 | 15.1 | 20 | 6 | 6 | 1 | 10 | 15 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.07 |
| SP | Gabbard, K.Gabbard, Kason >> | 24 | 2006 | L | 43 | 13 | 5 | 1 | 1 | 5.77 | .364 | 1.69 | 8.5 | 6.7 | 6.9 | 39.0 | 37 | 25 | 25 | 4 | 29 | 30 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.10 |