| SP | Buehrle, M.Buehrle, Mark >> | 26 | 2005 | L | 78 | 5 | 5 | 1 | 2 | 3.65 | .306 | 1.32 | 10.2 | 1.7 | 6.6 | 37.0 | 42 | 17 | 15 | 1 | 7 | 27 | 1 | 0 | 0 | 0 | 3 | 0 | 0 | 2.46 |
| SP | Suppan, J.Suppan, Jeff >> | 30 | 2005 | R | 48 | 4 | 4 | 1 | 2 | 5.04 | .324 | 1.44 | 9.7 | 3.2 | 6.1 | 25.0 | 27 | 14 | 14 | 4 | 9 | 17 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4.80 |
| SP | Kennedy, J.Kennedy, Joe >> | 26 | 2005 | L | 10 | 4 | 4 | 0 | 1 | 5.29 | .311 | 1.35 | 7.4 | 4.8 | 7.4 | 17.0 | 14 | 10 | 10 | 0 | 9 | 14 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.94 |
| SP | Garland, J.Garland, Jon >> | 26 | 2005 | R | 82 | 3 | 3 | 2 | 1 | 2.31 | .286 | 1.16 | 9.4 | 1.2 | 4.3 | 23.1 | 24 | 9 | 6 | 1 | 3 | 11 | 1 | 0 | 0 | 0 | 2 | 1 | 0 | 3.13 |
| SP | Saarloos, K.Saarloos, Kirk >> | 26 | 2005 | R | 39 | 3 | 3 | 1 | 2 | 6.61 | .355 | 1.65 | 13.5 | 1.7 | 7.3 | 16.1 | 24 | 12 | 12 | 4 | 3 | 13 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 5.19 |
| RP | Foulke, K.Foulke, Keith >> | 33 | 2005 | R | 26 | 8 | 0 | 1 | 1 | 2.16 | .306 | 1.32 | 11.3 | 1.1 | 7.9 | 8.1 | 10 | 3 | 2 | 0 | 1 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.63 |
| RP | Wunsch, K.Wunsch, Kelly >> | 33 | 2005 | L | 57 | 12 | 0 | 0 | 0 | 1.23 | .290 | 1.23 | 6.4 | 5.1 | 9.0 | 7.1 | 5 | 1 | 1 | 0 | 4 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.71 |
| SP | Hernandez, R.Hernandez, Runelvys >> | 27 | 2005 | R | 23 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | McCarthy, B.McCarthy, Brandon >> | 22 | 2005 | R | 88 | 1 | 0 | 1 | 0 | 0.00 | .300 | 0.86 | 9.0 | 0.0 | 0.0 | 2.1 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.50 |