| SP | Buehrle, M.Buehrle, Mark >> | 27 | 2006 | L | 35 | 10 | 10 | 2 | 3 | 5.30 | .358 | 1.66 | 11.8 | 3.2 | 5.5 | 54.1 | 71 | 37 | 32 | 11 | 19 | 33 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 5.54 |
| SP | Suppan, J.Suppan, Jeff >> | 31 | 2006 | R | 46 | 10 | 10 | 0 | 7 | 7.25 | .388 | 1.88 | 12.9 | 4.3 | 7.4 | 44.2 | 63 | 37 | 36 | 7 | 21 | 36 | 0 | 0 | 0 | 0 | 3 | 1 | 2 | 4.93 |
| SP | Garland, J.Garland, Jon # >> | 27 | 2006 | R | 49 | 10 | 10 | 2 | 5 | 5.80 | .312 | 1.34 | 10.7 | 1.5 | 8.2 | 54.1 | 64 | 36 | 35 | 10 | 9 | 49 | 0 | 0 | 0 | 0 | 5 | 1 | 0 | 4.15 |
| SP | Saarloos, K.Saarloos, Kirk >> | 27 | 2006 | R | 11 | 8 | 8 | 1 | 2 | 6.04 | .351 | 1.62 | 11.3 | 3.5 | 6.1 | 28.1 | 35 | 22 | 19 | 5 | 11 | 19 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.14 |
| SP | Hernandez, R.Hernandez, Runelvys >> | 28 | 2006 | R | 5 | 8 | 6 | 1 | 2 | 4.75 | .308 | 1.33 | 9.3 | 2.8 | 6.5 | 36.0 | 37 | 19 | 19 | 5 | 11 | 26 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 4.28 |
| RP | Foulke, K.Foulke, Keith >> | 34 | 2006 | R | 66 | 29 | 0 | 3 | 3 | 4.81 | .331 | 1.46 | 11.2 | 2.2 | 4.4 | 33.2 | 41 | 21 | 18 | 3 | 8 | 16 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 4.03 |
| RP | Haeger, C.Haeger, Charlie >> | 23 | 2006 | R | 79 | 16 | 0 | 0 | 0 | 1.35 | .333 | 1.43 | 6.9 | 6.2 | 9.7 | 13.1 | 10 | 2 | 2 | 0 | 9 | 14 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 3.15 |
| RP | McCarthy, B.McCarthy, Brandon >> | 23 | 2006 | R | 72 | 8 | 0 | 0 | 0 | 2.84 | .269 | 1.11 | 6.8 | 3.8 | 9.0 | 12.2 | 9 | 4 | 4 | 0 | 5 | 12 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.25 |
| RP | Kennedy, J.Kennedy, Joe >> | 27 | 2006 | L | 63 | 20 | 0 | 4 | 1 | 2.96 | .293 | 1.21 | 8.0 | 3.0 | 9.0 | 27.1 | 24 | 9 | 9 | 6 | 9 | 27 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.00 |