| SP | Liriano, F.Liriano, Francisco >> | 27 | 2010 | L | 77 | 7 | 7 | 2 | 1 | 3.43 | .351 | 1.52 | 10.9 | 2.8 | 9.0 | 42.0 | 51 | 16 | 16 | 4 | 13 | 42 | 0 | 0 | 0 | 0 | 2 | 4 | 2 | 3.45 |
| SP | Santana, J.Santana, Johan >> | 31 | 2010 | L | 84 | 7 | 7 | 4 | 3 | 3.00 | .266 | 1.09 | 8.4 | 1.4 | 7.1 | 57.0 | 53 | 19 | 19 | 8 | 9 | 45 | 2 | 0 | 0 | 0 | 4 | 0 | 0 | 3.72 |
| SP | Garza, M.Garza, Matt # >> | 27 | 2010 | R | 72 | 7 | 7 | 4 | 3 | 4.11 | .270 | 1.09 | 6.8 | 2.9 | 9.6 | 46.0 | 35 | 21 | 21 | 5 | 15 | 49 | 0 | 0 | 0 | 0 | 4 | 1 | 0 | 3.33 |
| SP | Slowey, K.Slowey, Kevin >> | 26 | 2010 | R | 53 | 6 | 6 | 1 | 2 | 4.80 | .348 | 1.60 | 11.7 | 2.7 | 6.6 | 30.0 | 39 | 18 | 16 | 1 | 9 | 22 | 0 | 0 | 0 | 0 | 3 | 0 | 2 | 2.87 |
| RP | Balfour, G.Balfour, Grant >> | 33 | 2010 | R | 85 | 19 | 0 | 2 | 0 | 2.22 | .215 | 0.82 | 5.3 | 2.3 | 7.5 | 24.1 | 14 | 6 | 6 | 0 | 6 | 20 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 2.08 |
| RP | Guerrier, M.Guerrier, Matt >> | 32 | 2010 | R | 77 | 13 | 0 | 1 | 0 | 0.54 | .219 | 0.78 | 3.9 | 3.4 | 6.8 | 16.2 | 7 | 1 | 1 | 0 | 6 | 12 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 2.81 |
| RP | Mijares, J.Mijares, Jose >> | 26 | 2010 | L | 50 | 6 | 0 | 1 | 2 | 7.50 | .379 | 1.83 | 13.5 | 3.0 | 6.0 | 6.0 | 9 | 5 | 5 | 0 | 2 | 4 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 2.67 |
| RP | Duensing, B.Duensing, Brian >> | 27 | 2010 | L | 64 | 4 | 0 | 0 | 1 | 7.11 | .345 | 1.58 | 12.0 | 3.0 | 7.5 | 6.1 | 8 | 5 | 5 | 0 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2.33 |
| RP | Hawkins, L.Hawkins, LaTroy >> | 38 | 2010 | R | 17 | 3 | 0 | 0 | 0 | 20.25 | .429 | 2.25 | 22.5 | 4.5 | 18.0 | 2.2 | 5 | 6 | 6 | 2 | 1 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 13.50 |
| SP | Kazmir, S.Kazmir, Scott >> | 26 | 2010 | L | 22 | 1 | 0 | 0 | 0 | 3.18 | .261 | 0.88 | 9.0 | 0.0 | 14.4 | 5.2 | 5 | 2 | 2 | 1 | 0 | 8 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.00 |