| SP | Mathewson, C.Mathewson, Christy + $ >> | 27 | 1908 | R | 90 | 35 | 35 | 15 | 9 | 3.66 | .260 | 1.03 | 7.9 | 1.4 | 4.4 | 243.1 | 213 | 102 | 99 | 28 | 38 | 118 | 11 | 0 | 0 | 3 | 20 | 5 | 1 | 4.06 |
| SP | Santana, J.Santana, Johan $ >> | 22 | 2004 | L | 86 | 34 | 34 | 15 | 11 | 3.62 | .268 | 1.08 | 7.6 | 2.1 | 7.1 | 219.0 | 186 | 93 | 88 | 25 | 51 | 172 | 6 | 0 | 0 | 0 | 21 | 3 | 4 | 3.65 |
| SP | Joss, A.Joss, Addie # + $ >> | 21 | 1908 | R | 80 | 34 | 34 | 12 | 12 | 5.16 | .302 | 1.28 | 9.6 | 2.0 | 3.1 | 212.2 | 227 | 127 | 122 | 38 | 46 | 73 | 4 | 0 | 0 | 0 | 14 | 3 | 1 | 5.33 |
| SP | Halladay, R.Halladay, Roy $ >> | 22 | 2011 | R | 36 | 34 | 33 | 8 | 14 | 5.44 | .323 | 1.40 | 10.2 | 2.5 | 5.6 | 154.0 | 174 | 97 | 93 | 23 | 42 | 96 | 5 | 0 | 0 | 1 | 11 | 4 | 2 | 4.59 |
| SP | Matlack, J.Matlack, Jon # $ >> | 23 | 1974 | L | 33 | 32 | 31 | 8 | 6 | 5.60 | .316 | 1.36 | 9.5 | 2.8 | 4.3 | 154.1 | 162 | 100 | 96 | 21 | 48 | 74 | 2 | 0 | 0 | 1 | 10 | 4 | 1 | 4.82 |
| RP | Konstanty, J.Konstanty, Jim † $ >> | 30 | 1950 | R | 70 | 72 | 0 | 18 | 3 | 2.57 | .217 | 0.82 | 5.7 | 1.7 | 4.3 | 185.2 | 118 | 58 | 53 | 12 | 35 | 88 | 0 | 1 | 1 | 0 | 0 | 1 | 2 | 3.48 |
| RP | Green, C.Green, Chad + $ >> | 24 | 2021 | R | 68 | 62 | 0 | 4 | 6 | 4.09 | .295 | 1.21 | 8.9 | 2.1 | 6.9 | 92.1 | 91 | 47 | 42 | 20 | 21 | 71 | 0 | 3 | 3 | 0 | 0 | 4 | 3 | 5.10 |
| CL | Kuo, H.Kuo, Hong-Chih † + >> | 20 | 2010 | L | 75 | 71 | 0 | 6 | 5 | 2.72 | .256 | 1.00 | 5.9 | 3.3 | 8.5 | 72.2 | 47 | 25 | 22 | 3 | 26 | 68 | 0 | 41 | 5 | 0 | 0 | 2 | 3 | 2.82 |
| RP | Vande Berg, E.Vande Berg, Ed $ >> | 23 | 1982 | L | 61 | 46 | 0 | 5 | 2 | 3.10 | .251 | 0.96 | 6.8 | 2.0 | 5.1 | 72.2 | 54 | 25 | 25 | 5 | 16 | 41 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 3.56 |
| RP | Niedenfuer, T.Niedenfuer, Tom $ >> | 24 | 1985 | R | 49 | 41 | 0 | 4 | 1 | 3.45 | .286 | 1.17 | 8.0 | 2.6 | 8.3 | 60.0 | 53 | 24 | 23 | 5 | 17 | 55 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 3.20 |
| RP | Rodriguez, F.Rodriguez, Felix $ >> | 22 | 2001 | R | 48 | 27 | 0 | 0 | 1 | 2.63 | .231 | 0.88 | 5.6 | 2.4 | 6.6 | 37.2 | 23 | 11 | 11 | 7 | 10 | 27 | 0 | 1 | 0 | 0 | 0 | 1 | 3 | 4.89 |
| SP | Wheeler, Z.Wheeler, Zack >> | 38 | 2021 | R | 44 | 9 | 1 | 2 | 1 | 6.26 | .289 | 1.22 | 9.0 | 2.0 | 7.0 | 23.0 | 23 | 17 | 16 | 7 | 5 | 18 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 6.04 |