| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 96 | 43 | 43 | 16 | 21 | 4.31 | .299 | 1.26 | 9.0 | 2.4 | 6.0 | 271.2 | 270 | 132 | 130 | 32 | 71 | 181 | 5 | 0 | 0 | 1 | 23 | 7 | 3 | 4.06 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 95 | 43 | 43 | 18 | 16 | 3.34 | .275 | 1.09 | 7.7 | 2.2 | 7.2 | 301.2 | 257 | 122 | 112 | 35 | 72 | 241 | 9 | 0 | 0 | 2 | 30 | 14 | 4 | 3.77 |
| SP | Kershaw, C.Kershaw, Clayton # >> | 27 | 2015 | L | 98 | 43 | 43 | 14 | 17 | 3.76 | .300 | 1.25 | 8.5 | 2.7 | 10.6 | 277.2 | 263 | 128 | 116 | 42 | 84 | 326 | 6 | 0 | 0 | 2 | 28 | 10 | 11 | 3.64 |
| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 88 | 40 | 40 | 14 | 18 | 4.16 | .324 | 1.42 | 8.6 | 4.2 | 7.4 | 240.1 | 228 | 123 | 111 | 34 | 113 | 198 | 1 | 0 | 0 | 1 | 21 | 4 | 5 | 4.65 |
| RP | Wheeler, D.Wheeler, Dan >> | 28 | 2005 | R | 86 | 75 | 0 | 4 | 4 | 3.01 | .289 | 1.20 | 8.0 | 2.8 | 8.3 | 83.2 | 74 | 33 | 28 | 9 | 26 | 77 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 3.57 |
| RP | Springer, R.Springer, Russ >> | 37 | 2005 | R | 65 | 37 | 0 | 0 | 1 | 5.08 | .344 | 1.46 | 9.8 | 3.5 | 7.6 | 33.2 | 36 | 20 | 19 | 8 | 13 | 28 | 0 | 0 | 0 | 0 | 0 | 4 | 1 | 6.00 |
| CL | Jansen, K.Jansen, Kenley >> | 27 | 2015 | R | 99 | 56 | 0 | 1 | 4 | 2.63 | .256 | 1.01 | 7.4 | 1.8 | 9.9 | 51.1 | 42 | 18 | 15 | 7 | 10 | 56 | 0 | 38 | 2 | 0 | 0 | 1 | 0 | 3.24 |
| SU | Garcia, Y.Garcia, Yimi >> | 24 | 2015 | R | 87 | 27 | 0 | 1 | 2 | 3.82 | .287 | 1.17 | 8.4 | 2.4 | 9.9 | 30.2 | 28 | 16 | 13 | 3 | 8 | 33 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 3.00 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 79 | 26 | 0 | 2 | 1 | 2.67 | .278 | 1.12 | 7.4 | 2.8 | 7.7 | 94.1 | 77 | 32 | 28 | 7 | 29 | 80 | 0 | 2 | 0 | 0 | 0 | 3 | 2 | 3.29 |