| SP | Kershaw, C.Kershaw, Clayton $ >> | 28 | 2016 | L | 99 | 26 | 26 | 11 | 11 | 4.30 | .290 | 1.20 | 9.1 | 1.8 | 8.9 | 173.2 | 175 | 84 | 83 | 11 | 34 | 171 | 6 | 0 | 0 | 0 | 16 | 4 | 4 | 2.51 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 25 | 25 | 10 | 7 | 4.46 | .330 | 1.46 | 8.3 | 4.9 | 8.5 | 153.1 | 141 | 79 | 76 | 17 | 83 | 144 | 1 | 0 | 0 | 1 | 12 | 3 | 3 | 4.25 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 25 | 25 | 8 | 7 | 5.72 | .333 | 1.50 | 9.6 | 3.9 | 8.8 | 137.0 | 146 | 93 | 87 | 22 | 59 | 134 | 1 | 0 | 0 | 0 | 11 | 0 | 2 | 4.42 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 25 | 25 | 11 | 7 | 4.27 | .301 | 1.29 | 8.7 | 2.9 | 5.0 | 177.0 | 171 | 86 | 84 | 23 | 57 | 98 | 5 | 0 | 0 | 3 | 11 | 1 | 3 | 4.56 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 67 | 26 | 24 | 7 | 15 | 4.81 | .335 | 1.47 | 9.3 | 3.9 | 7.7 | 155.1 | 160 | 86 | 83 | 24 | 68 | 133 | 1 | 0 | 0 | 0 | 12 | 7 | 4 | 4.75 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 54 | 0 | 3 | 3 | 3.45 | .295 | 1.17 | 6.8 | 3.8 | 8.2 | 57.1 | 43 | 26 | 22 | 6 | 24 | 52 | 0 | 27 | 2 | 0 | 0 | 5 | 3 | 4.07 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 83 | 63 | 0 | 7 | 2 | 2.87 | .284 | 1.15 | 5.7 | 4.7 | 7.5 | 78.1 | 49 | 26 | 25 | 7 | 41 | 65 | 0 | 0 | 4 | 0 | 0 | 3 | 1 | 4.19 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 49 | 0 | 1 | 0 | 3.26 | .329 | 1.47 | 7.3 | 6.1 | 9.6 | 49.2 | 40 | 23 | 18 | 3 | 33 | 52 | 0 | 1 | 2 | 0 | 0 | 0 | 3 | 3.69 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 44 | 0 | 4 | 3 | 5.19 | .333 | 1.50 | 8.7 | 4.8 | 9.3 | 52.0 | 50 | 31 | 30 | 7 | 28 | 54 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 4.29 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 15 | 0 | 1 | 0 | 4.20 | .323 | 1.43 | 10.5 | 2.4 | 4.5 | 30.0 | 35 | 15 | 14 | 5 | 8 | 15 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 4.97 |