| SP | Scherzer, M.Scherzer, Max $ >> | 33 | 2017 | R | 95 | 22 | 22 | 8 | 5 | 3.83 | .309 | 1.32 | 8.9 | 3.0 | 7.8 | 145.2 | 143 | 62 | 62 | 14 | 49 | 125 | 1 | 0 | 0 | 0 | 15 | 3 | 0 | 3.61 |
| SP | Maddux, G.Maddux, Greg † >> | 29 | 1995 | R | 89 | 21 | 21 | 12 | 7 | 3.62 | .273 | 1.11 | 8.2 | 1.8 | 5.3 | 154.1 | 141 | 69 | 62 | 13 | 31 | 90 | 6 | 0 | 0 | 1 | 11 | 2 | 4 | 3.57 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 21 | 21 | 7 | 10 | 5.43 | .331 | 1.46 | 9.7 | 3.5 | 4.8 | 134.1 | 144 | 90 | 81 | 17 | 52 | 72 | 4 | 0 | 0 | 0 | 9 | 3 | 1 | 4.81 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 20 | 20 | 6 | 10 | 6.30 | .358 | 1.65 | 10.5 | 4.4 | 5.2 | 120.0 | 140 | 93 | 84 | 16 | 58 | 69 | 1 | 0 | 0 | 0 | 9 | 3 | 4 | 5.11 |
| CL | Street, H.Street, Huston † >> | 29 | 2012 | R | 96 | 40 | 0 | 3 | 1 | 1.89 | .267 | 1.03 | 5.2 | 4.2 | 7.9 | 47.2 | 27 | 13 | 10 | 2 | 22 | 41 | 0 | 23 | 5 | 0 | 0 | 3 | 1 | 3.40 |
| SU | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 34 | 0 | 0 | 1 | 3.68 | .295 | 1.23 | 9.5 | 1.8 | 8.3 | 36.2 | 38 | 15 | 15 | 7 | 7 | 33 | 0 | 4 | 2 | 0 | 0 | 1 | 0 | 4.36 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 45 | 0 | 6 | 0 | 2.67 | .247 | 0.94 | 5.0 | 3.5 | 8.0 | 54.0 | 30 | 16 | 16 | 4 | 21 | 48 | 0 | 1 | 1 | 0 | 0 | 2 | 6 | 3.46 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 27 | 0 | 3 | 3 | 3.30 | .268 | 1.07 | 7.2 | 2.4 | 9.0 | 30.0 | 24 | 11 | 11 | 4 | 8 | 30 | 0 | 1 | 0 | 0 | 0 | 1 | 2 | 3.63 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 72 | 24 | 0 | 1 | 1 | 4.15 | .278 | 1.15 | 8.6 | 2.1 | 8.6 | 21.2 | 20 | 10 | 10 | 2 | 5 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.05 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 16 | 1 | 4 | 1 | 7.04 | .372 | 1.76 | 10.8 | 5.2 | 5.2 | 61.1 | 73 | 48 | 48 | 12 | 35 | 35 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 6.18 |