| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 26 | 26 | 8 | 9 | 4.15 | .307 | 1.30 | 8.2 | 3.5 | 8.0 | 169.1 | 154 | 80 | 78 | 27 | 66 | 150 | 1 | 0 | 0 | 1 | 14 | 5 | 4 | 4.56 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 25 | 25 | 8 | 12 | 4.82 | .332 | 1.47 | 10.4 | 2.8 | 4.9 | 175.2 | 203 | 110 | 94 | 25 | 55 | 95 | 7 | 0 | 0 | 1 | 10 | 4 | 3 | 4.78 |
| SP | Harden, R.Harden, Rich # >> | 27 | 2008 | R | 61 | 23 | 23 | 3 | 7 | 4.73 | .331 | 1.47 | 8.8 | 4.5 | 9.2 | 110.1 | 107 | 65 | 58 | 19 | 55 | 112 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 4.76 |
| SP | Liriano, F.Liriano, Francisco # >> | 23 | 2006 | L | 58 | 24 | 24 | 0 | 9 | 6.58 | .381 | 1.80 | 11.7 | 4.6 | 7.9 | 94.1 | 122 | 71 | 69 | 14 | 48 | 83 | 0 | 0 | 0 | 0 | 0 | 4 | 2 | 4.83 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 65 | 0 | 7 | 5 | 3.53 | .271 | 1.10 | 7.1 | 2.9 | 8.2 | 97.0 | 76 | 39 | 38 | 9 | 31 | 88 | 0 | 3 | 3 | 0 | 0 | 1 | 2 | 3.38 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 60 | 0 | 7 | 2 | 4.16 | .299 | 1.25 | 8.0 | 3.2 | 9.1 | 84.1 | 75 | 40 | 39 | 14 | 30 | 85 | 0 | 6 | 3 | 0 | 0 | 3 | 5 | 4.32 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 54 | 0 | 3 | 8 | 4.92 | .324 | 1.41 | 8.7 | 4.1 | 5.8 | 93.1 | 90 | 57 | 51 | 11 | 42 | 60 | 0 | 7 | 3 | 0 | 0 | 2 | 4 | 4.67 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 4 | 2 | 1 | 1 | 7.94 | .414 | 2.12 | 12.3 | 7.4 | 4.9 | 11.1 | 15 | 10 | 10 | 4 | 9 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 9.09 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 29 | 0 | 5 | 4 | 3.82 | .305 | 1.29 | 9.4 | 2.3 | 4.8 | 70.2 | 73 | 32 | 30 | 14 | 18 | 37 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 5.40 |