| SP | McNally, D.McNally, Dave # >> | 26 | 1968 | L | 96 | 11 | 11 | 4 | 4 | 5.32 | .310 | 1.34 | 10.3 | 1.9 | 5.0 | 67.2 | 77 | 41 | 40 | 9 | 14 | 37 | 1 | 0 | 0 | 0 | 4 | 0 | 1 | 4.27 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 10 | 10 | 2 | 5 | 4.91 | .362 | 1.68 | 11.3 | 3.9 | 3.2 | 62.1 | 78 | 34 | 34 | 6 | 27 | 22 | 2 | 0 | 0 | 0 | 4 | 1 | 1 | 4.90 |
| CL | Doolittle, S.Doolittle, Sean $$ >> | 31 | 2018 | L | 99 | 18 | 0 | 1 | 1 | 3.20 | .280 | 1.12 | 5.7 | 4.7 | 8.5 | 19.2 | 12 | 7 | 7 | 2 | 10 | 18 | 0 | 7 | 1 | 0 | 0 | 1 | 1 | 4.21 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 30 | 0 | 2 | 1 | 3.03 | .279 | 1.16 | 8.4 | 2.3 | 8.7 | 32.2 | 30 | 11 | 11 | 2 | 8 | 31 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.63 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 22 | 0 | 1 | 0 | 2.90 | .177 | 0.65 | 3.5 | 2.3 | 4.4 | 31.0 | 12 | 10 | 10 | 3 | 8 | 15 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.06 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 15 | 0 | 4 | 0 | 4.15 | .373 | 1.73 | 11.1 | 4.8 | 9.0 | 17.1 | 21 | 9 | 8 | 2 | 9 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.29 |