| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 10 | 10 | 4 | 3 | 4.06 | .331 | 1.45 | 10.6 | 2.5 | 8.6 | 62.0 | 73 | 30 | 28 | 8 | 17 | 59 | 0 | 0 | 0 | 0 | 6 | 2 | 0 | 3.69 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 10 | 10 | 4 | 4 | 4.66 | .279 | 1.15 | 6.6 | 3.9 | 8.9 | 63.2 | 46 | 34 | 33 | 6 | 27 | 62 | 1 | 0 | 0 | 0 | 5 | 1 | 5 | 3.60 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 10 | 10 | 4 | 4 | 4.67 | .321 | 1.36 | 10.4 | 1.9 | 4.4 | 71.1 | 82 | 40 | 37 | 4 | 15 | 35 | 1 | 0 | 0 | 0 | 5 | 4 | 3 | 3.55 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 10 | 10 | 4 | 3 | 6.24 | .340 | 1.53 | 9.6 | 4.2 | 5.1 | 62.0 | 66 | 43 | 43 | 11 | 29 | 35 | 1 | 0 | 0 | 0 | 4 | 1 | 0 | 5.63 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 10 | 10 | 1 | 6 | 7.85 | .399 | 1.99 | 13.6 | 4.4 | 5.4 | 57.1 | 86 | 55 | 50 | 10 | 28 | 34 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 5.56 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 23 | 0 | 0 | 4 | 8.26 | .366 | 1.69 | 12.5 | 2.9 | 9.3 | 28.1 | 39 | 30 | 26 | 5 | 9 | 29 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.32 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 26 | 0 | 3 | 2 | 3.51 | .291 | 1.20 | 7.6 | 3.3 | 7.6 | 33.1 | 28 | 17 | 13 | 5 | 12 | 28 | 0 | 3 | 1 | 0 | 0 | 1 | 0 | 4.45 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 24 | 0 | 0 | 0 | 1.80 | .318 | 1.36 | 7.2 | 5.0 | 7.2 | 25.0 | 20 | 5 | 5 | 0 | 14 | 20 | 0 | 6 | 0 | 0 | 0 | 1 | 1 | 3.20 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 15 | 0 | 1 | 1 | 6.06 | .372 | 1.78 | 9.6 | 6.8 | 5.6 | 16.1 | 17 | 12 | 11 | 1 | 12 | 10 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 4.81 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 50 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 58 | 4 | 0 | 0 | 1 | 6.14 | .450 | 2.45 | 16.7 | 6.4 | 2.6 | 7.1 | 13 | 12 | 5 | 0 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 4.57 |