| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 34 | 34 | 14 | 10 | 3.76 | .297 | 1.24 | 8.7 | 2.4 | 9.0 | 225.0 | 218 | 100 | 94 | 30 | 60 | 225 | 0 | 0 | 0 | 0 | 25 | 7 | 0 | 3.63 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 33 | 33 | 13 | 13 | 4.79 | .312 | 1.34 | 8.3 | 3.7 | 8.1 | 206.2 | 191 | 121 | 110 | 29 | 85 | 185 | 1 | 0 | 0 | 0 | 17 | 5 | 10 | 4.34 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 32 | 32 | 16 | 12 | 4.00 | .303 | 1.27 | 9.6 | 1.8 | 5.1 | 236.1 | 252 | 118 | 105 | 21 | 47 | 133 | 6 | 0 | 0 | 0 | 18 | 9 | 4 | 3.74 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 32 | 32 | 12 | 12 | 5.20 | .325 | 1.41 | 9.5 | 3.2 | 5.4 | 214.2 | 227 | 130 | 124 | 23 | 76 | 129 | 4 | 0 | 0 | 1 | 15 | 7 | 0 | 4.36 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 31 | 31 | 3 | 18 | 8.08 | .392 | 1.92 | 12.8 | 4.4 | 4.8 | 166.0 | 237 | 159 | 149 | 29 | 81 | 88 | 0 | 0 | 0 | 0 | 6 | 3 | 3 | 5.73 |
| RP | Jansen, K.Jansen, Kenley # >> | 28 | 2016 | R | 97 | 84 | 0 | 3 | 9 | 5.31 | .308 | 1.31 | 9.5 | 2.3 | 9.9 | 105.0 | 111 | 68 | 62 | 19 | 27 | 116 | 0 | 8 | 4 | 0 | 0 | 2 | 6 | 3.97 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 77 | 0 | 4 | 4 | 4.27 | .302 | 1.28 | 7.3 | 4.2 | 7.8 | 97.0 | 79 | 53 | 46 | 17 | 45 | 84 | 0 | 7 | 4 | 0 | 0 | 2 | 0 | 5.00 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 64 | 0 | 1 | 8 | 3.18 | .325 | 1.42 | 6.7 | 6.2 | 8.1 | 70.2 | 52 | 27 | 25 | 5 | 48 | 63 | 0 | 9 | 4 | 0 | 0 | 2 | 2 | 4.27 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 50 | 0 | 3 | 3 | 3.93 | .335 | 1.50 | 8.2 | 5.4 | 5.4 | 68.2 | 62 | 35 | 30 | 5 | 41 | 41 | 0 | 5 | 1 | 0 | 0 | 1 | 2 | 4.60 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Tanana, F.Tanana, Frank >> | 23 | 1976 | L | 57 | 11 | 0 | 0 | 3 | 7.07 | .408 | 2.07 | 13.5 | 5.1 | 4.5 | 14.0 | 21 | 18 | 11 | 1 | 8 | 7 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 4.64 |