| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 16 | 16 | 4 | 6 | 5.75 | .320 | 1.34 | 9.3 | 2.7 | 8.9 | 83.0 | 86 | 58 | 53 | 16 | 25 | 82 | 0 | 0 | 0 | 0 | 8 | 6 | 0 | 4.65 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 89 | 16 | 16 | 4 | 7 | 6.21 | .344 | 1.54 | 10.5 | 3.3 | 7.3 | 84.0 | 98 | 58 | 58 | 17 | 31 | 68 | 0 | 0 | 0 | 0 | 5 | 3 | 1 | 5.23 |
| SP | Marichal, J.Marichal, Juan # >> | 29 | 1966 | R | 76 | 16 | 15 | 6 | 6 | 5.46 | .314 | 1.33 | 9.8 | 2.3 | 5.8 | 92.1 | 100 | 58 | 56 | 18 | 23 | 59 | 3 | 0 | 0 | 0 | 5 | 4 | 2 | 5.14 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 71 | 16 | 15 | 2 | 5 | 7.77 | .386 | 1.83 | 13.1 | 3.4 | 4.1 | 68.1 | 99 | 64 | 59 | 14 | 26 | 31 | 1 | 1 | 0 | 0 | 2 | 4 | 2 | 6.09 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 44 | 0 | 6 | 6 | 4.23 | .288 | 1.14 | 7.4 | 2.9 | 8.8 | 55.1 | 45 | 26 | 26 | 8 | 18 | 54 | 0 | 13 | 6 | 0 | 0 | 4 | 1 | 4.13 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 45 | 0 | 2 | 2 | 5.34 | .348 | 1.55 | 8.4 | 5.7 | 9.9 | 57.1 | 53 | 36 | 34 | 7 | 36 | 63 | 0 | 1 | 3 | 0 | 0 | 3 | 0 | 4.44 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 45 | 0 | 3 | 0 | 2.12 | .249 | 0.98 | 6.6 | 2.3 | 8.4 | 59.1 | 43 | 14 | 14 | 4 | 15 | 55 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.83 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 35 | 0 | 5 | 1 | 3.62 | .297 | 1.27 | 9.0 | 2.6 | 9.4 | 49.2 | 49 | 21 | 20 | 7 | 14 | 51 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.63 |