| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 26 | 26 | 9 | 9 | 3.62 | .287 | 1.18 | 8.2 | 2.4 | 9.5 | 159.0 | 145 | 65 | 64 | 21 | 42 | 168 | 0 | 0 | 0 | 0 | 17 | 5 | 0 | 3.49 |
| SP | Arrieta, J.Arrieta, Jake # >> | 29 | 2015 | R | 92 | 25 | 25 | 9 | 9 | 4.91 | .308 | 1.31 | 8.9 | 2.9 | 7.3 | 150.1 | 149 | 85 | 82 | 19 | 48 | 121 | 2 | 0 | 0 | 0 | 12 | 4 | 1 | 4.07 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 25 | 25 | 6 | 9 | 5.31 | .335 | 1.51 | 9.8 | 3.8 | 4.8 | 140.2 | 153 | 91 | 83 | 18 | 59 | 75 | 0 | 0 | 0 | 0 | 11 | 1 | 0 | 4.89 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 26 | 25 | 9 | 11 | 5.55 | .331 | 1.48 | 9.6 | 3.8 | 6.6 | 147.2 | 156 | 92 | 91 | 25 | 62 | 107 | 1 | 0 | 0 | 0 | 11 | 1 | 4 | 5.04 |
| CL | Kimbrel, C.Kimbrel, Craig † >> | 24 | 2012 | R | 100 | 70 | 0 | 2 | 5 | 3.36 | .310 | 1.32 | 6.8 | 5.0 | 9.5 | 75.0 | 57 | 30 | 28 | 8 | 42 | 79 | 0 | 41 | 2 | 0 | 0 | 2 | 5 | 4.04 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 74 | 0 | 5 | 2 | 2.31 | .249 | 0.97 | 5.1 | 3.7 | 10.5 | 89.2 | 50 | 25 | 23 | 6 | 37 | 104 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 2.85 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 92 | 67 | 0 | 5 | 2 | 5.52 | .329 | 1.47 | 8.9 | 4.5 | 8.4 | 76.2 | 75 | 47 | 47 | 16 | 38 | 71 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 5.37 |