| SP | Ranaudo, A.Ranaudo, Anthony >> | 28 | 2014 | R | 89 | 34 | 33 | 12 | 11 | 4.29 | .314 | 1.33 | 8.1 | 3.9 | 6.5 | 218.0 | 196 | 108 | 104 | 31 | 95 | 158 | 0 | 0 | 0 | 0 | 17 | 8 | 3 | 4.82 |
| SP | Buchholz, C.Buchholz, Clay >> | 32 | 2013 | R | 77 | 35 | 35 | 10 | 10 | 4.95 | .308 | 1.30 | 8.0 | 3.7 | 7.0 | 167.1 | 149 | 93 | 92 | 26 | 69 | 129 | 0 | 0 | 0 | 0 | 12 | 5 | 4 | 4.81 |
| SP | Beckett, J.Beckett, Josh # >> | 32 | 2011 | R | 74 | 29 | 27 | 13 | 10 | 4.13 | .296 | 1.24 | 8.1 | 3.1 | 6.8 | 172.1 | 154 | 81 | 79 | 28 | 59 | 129 | 2 | 1 | 0 | 2 | 16 | 4 | 1 | 4.72 |
| SP | Porcello, R.Porcello, Rick >> | 33 | 2016 | R | 70 | 35 | 35 | 10 | 9 | 4.50 | .312 | 1.33 | 9.8 | 2.2 | 6.8 | 168.0 | 183 | 89 | 84 | 38 | 41 | 127 | 1 | 0 | 0 | 1 | 15 | 5 | 0 | 5.25 |
| SP | Rodriguez, E.Rodriguez, Eduardo # >> | 33 | 2018 | L | 63 | 37 | 37 | 10 | 12 | 4.93 | .287 | 1.19 | 8.5 | 2.2 | 10.6 | 201.0 | 189 | 113 | 110 | 38 | 50 | 236 | 1 | 0 | 0 | 1 | 17 | 4 | 2 | 3.92 |
| RP | Uehara, K.Uehara, Koji >> | 37 | 2011 | R | 88 | 104 | 0 | 7 | 7 | 3.05 | .266 | 1.07 | 7.3 | 2.3 | 9.1 | 124.0 | 101 | 42 | 42 | 9 | 32 | 125 | 0 | 1 | 3 | 0 | 0 | 2 | 0 | 2.75 |
| RP | Miller, A.Miller, Andrew >> | 33 | 2014 | L | 85 | 105 | 0 | 9 | 7 | 4.88 | .309 | 1.28 | 7.1 | 4.5 | 11.5 | 97.2 | 76 | 53 | 53 | 6 | 49 | 124 | 0 | 3 | 2 | 0 | 0 | 6 | 5 | 2.95 |
| RP | Kimbrel, C.Kimbrel, Craig # >> | 24 | 2011 | R | 77 | 94 | 0 | 7 | 2 | 3.62 | .296 | 1.25 | 7.8 | 3.5 | 9.6 | 87.0 | 75 | 36 | 35 | 10 | 34 | 93 | 0 | 10 | 2 | 0 | 0 | 1 | 4 | 3.56 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 32 | 2011 | R | 63 | 47 | 0 | 4 | 3 | 4.40 | .332 | 1.44 | 9.4 | 3.6 | 10.9 | 43.0 | 45 | 21 | 21 | 9 | 17 | 52 | 0 | 9 | 6 | 0 | 0 | 2 | 1 | 4.63 |
| RP | Tazawa, J.Tazawa, Junichi >> | 28 | 2012 | R | 79 | 43 | 0 | 1 | 0 | 2.22 | .277 | 1.09 | 8.0 | 1.9 | 10.4 | 56.2 | 50 | 15 | 14 | 4 | 12 | 65 | 0 | 2 | 0 | 0 | 0 | 3 | 0 | 2.41 |