| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 35 | 35 | 18 | 11 | 3.80 | .286 | 1.18 | 7.0 | 3.6 | 8.5 | 246.0 | 192 | 106 | 104 | 35 | 98 | 232 | 4 | 0 | 0 | 0 | 21 | 5 | 4 | 4.22 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 34 | 34 | 14 | 16 | 4.14 | .287 | 1.17 | 7.9 | 2.7 | 8.3 | 230.2 | 203 | 115 | 106 | 27 | 68 | 213 | 6 | 0 | 0 | 1 | 20 | 7 | 7 | 3.65 |
| SP | Cueto, J.Cueto, Johnny † # >> | 28 | 2014 | R | 75 | 32 | 32 | 15 | 10 | 3.23 | .291 | 1.19 | 7.7 | 3.1 | 6.1 | 239.1 | 205 | 100 | 86 | 29 | 81 | 161 | 9 | 0 | 0 | 1 | 22 | 9 | 4 | 4.36 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 31 | 31 | 16 | 8 | 3.85 | .301 | 1.28 | 7.1 | 4.4 | 3.6 | 217.1 | 171 | 100 | 93 | 20 | 107 | 86 | 2 | 0 | 0 | 1 | 16 | 3 | 2 | 4.93 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 88 | 0 | 4 | 3 | 3.83 | .304 | 1.27 | 7.4 | 4.1 | 8.3 | 120.0 | 98 | 54 | 51 | 15 | 54 | 110 | 0 | 16 | 4 | 0 | 0 | 5 | 4 | 4.27 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 76 | 74 | 0 | 1 | 3 | 3.98 | .348 | 1.58 | 8.5 | 5.8 | 8.4 | 86.0 | 81 | 42 | 38 | 8 | 55 | 80 | 0 | 8 | 4 | 0 | 0 | 2 | 9 | 4.34 |
| RP | Niedenfuer, T.Niedenfuer, Tom >> | 24 | 1983 | R | 60 | 64 | 0 | 4 | 3 | 3.90 | .312 | 1.30 | 8.6 | 3.1 | 3.9 | 67.0 | 64 | 30 | 29 | 7 | 23 | 29 | 0 | 14 | 3 | 0 | 0 | 4 | 2 | 4.70 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 53 | 37 | 0 | 6 | 5 | 3.54 | .289 | 1.20 | 8.7 | 2.2 | 6.3 | 53.1 | 51 | 23 | 21 | 5 | 13 | 37 | 0 | 5 | 2 | 0 | 0 | 1 | 0 | 3.62 |
| SP | Chance, D.Chance, Dean >> | 23 | 1964 | R | 53 | 8 | 0 | 0 | 1 | 10.20 | .451 | 2.47 | 14.4 | 7.8 | 4.2 | 15.0 | 24 | 21 | 17 | 3 | 13 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 7.27 |