| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 22 | 22 | 7 | 6 | 3.45 | .320 | 1.40 | 8.9 | 3.8 | 4.5 | 127.2 | 125 | 58 | 49 | 9 | 54 | 63 | 0 | 0 | 0 | 0 | 13 | 1 | 1 | 4.23 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 21 | 21 | 7 | 10 | 5.40 | .342 | 1.52 | 10.3 | 3.4 | 4.5 | 123.1 | 141 | 79 | 74 | 12 | 47 | 61 | 2 | 0 | 0 | 0 | 7 | 4 | 4 | 4.52 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 68 | 22 | 21 | 7 | 9 | 5.07 | .332 | 1.48 | 10.2 | 3.1 | 6.9 | 124.1 | 141 | 74 | 70 | 24 | 43 | 95 | 2 | 0 | 0 | 0 | 10 | 1 | 0 | 5.05 |
| CL | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 60 | 0 | 6 | 7 | 3.60 | .306 | 1.32 | 7.1 | 4.8 | 8.2 | 75.0 | 59 | 34 | 30 | 7 | 40 | 68 | 0 | 27 | 6 | 0 | 0 | 0 | 0 | 4.00 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 53 | 0 | 1 | 1 | 4.05 | .280 | 1.13 | 7.1 | 3.2 | 8.7 | 60.0 | 47 | 30 | 27 | 9 | 21 | 58 | 0 | 2 | 3 | 0 | 0 | 2 | 0 | 4.17 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 64 | 0 | 3 | 3 | 3.65 | .269 | 1.08 | 6.3 | 3.5 | 5.7 | 88.2 | 62 | 39 | 36 | 10 | 34 | 56 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 4.43 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 77 | 49 | 0 | 7 | 1 | 2.95 | .267 | 1.06 | 7.7 | 1.8 | 7.0 | 64.0 | 55 | 25 | 21 | 3 | 13 | 50 | 0 | 1 | 1 | 0 | 0 | 2 | 0 | 2.75 |