| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 34 | 34 | 14 | 15 | 4.76 | .312 | 1.32 | 9.2 | 2.7 | 6.3 | 230.2 | 235 | 128 | 122 | 19 | 69 | 162 | 2 | 0 | 0 | 0 | 17 | 10 | 6 | 3.70 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 33 | 33 | 12 | 17 | 4.92 | .311 | 1.35 | 9.7 | 2.4 | 4.8 | 225.0 | 243 | 131 | 123 | 26 | 60 | 119 | 2 | 0 | 0 | 1 | 16 | 2 | 2 | 4.27 |
| SP | Clemens, R.Clemens, Roger # >> | 24 | 1986 | R | 69 | 32 | 32 | 15 | 10 | 4.39 | .317 | 1.37 | 9.0 | 3.4 | 5.8 | 236.0 | 235 | 128 | 115 | 36 | 89 | 151 | 2 | 0 | 0 | 0 | 19 | 5 | 5 | 4.90 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 32 | 32 | 15 | 6 | 3.81 | .308 | 1.31 | 8.7 | 3.1 | 8.1 | 222.0 | 214 | 100 | 94 | 17 | 77 | 199 | 1 | 0 | 0 | 0 | 22 | 5 | 13 | 3.31 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 79 | 0 | 8 | 4 | 4.75 | .336 | 1.49 | 9.0 | 4.5 | 8.4 | 119.1 | 119 | 66 | 63 | 21 | 59 | 111 | 0 | 2 | 2 | 0 | 0 | 3 | 3 | 4.99 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 55 | 0 | 4 | 0 | 3.47 | .290 | 1.21 | 7.4 | 3.5 | 8.8 | 57.0 | 47 | 22 | 22 | 7 | 22 | 56 | 0 | 2 | 3 | 0 | 0 | 1 | 3 | 3.84 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 39 | 0 | 0 | 0 | 3.92 | .330 | 1.43 | 9.0 | 4.0 | 8.6 | 41.1 | 41 | 20 | 18 | 7 | 18 | 39 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.78 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 50 | 0 | 1 | 1 | 2.75 | .263 | 1.05 | 5.4 | 4.2 | 11.3 | 52.1 | 31 | 18 | 16 | 3 | 24 | 65 | 0 | 4 | 3 | 0 | 0 | 1 | 2 | 2.69 |
| CL | Eckersley, D.Eckersley, Dennis † >> | 36 | 1990 | R | 88 | 64 | 0 | 5 | 11 | 3.18 | .284 | 1.17 | 8.7 | 1.9 | 8.6 | 62.1 | 60 | 27 | 22 | 7 | 13 | 59 | 0 | 43 | 4 | 0 | 0 | 1 | 0 | 3.24 |