| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 23 | 23 | 7 | 14 | 4.35 | .290 | 1.22 | 8.3 | 2.6 | 4.8 | 176.0 | 163 | 95 | 85 | 16 | 51 | 94 | 8 | 0 | 0 | 0 | 9 | 2 | 2 | 4.02 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 21 | 21 | 7 | 7 | 4.72 | .324 | 1.43 | 9.4 | 3.4 | 6.1 | 141.0 | 148 | 79 | 74 | 13 | 53 | 96 | 3 | 0 | 0 | 1 | 11 | 2 | 3 | 4.01 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 21 | 21 | 5 | 3 | 4.76 | .318 | 1.36 | 8.0 | 4.2 | 5.7 | 121.0 | 108 | 67 | 64 | 19 | 57 | 76 | 0 | 0 | 0 | 0 | 11 | 4 | 1 | 5.30 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 56 | 0 | 6 | 2 | 1.72 | .288 | 1.16 | 6.4 | 4.2 | 6.1 | 62.2 | 44 | 14 | 12 | 3 | 29 | 42 | 0 | 5 | 2 | 0 | 0 | 3 | 0 | 3.82 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 44 | 0 | 3 | 4 | 3.62 | .323 | 1.41 | 9.9 | 2.9 | 11.2 | 49.2 | 54 | 25 | 20 | 4 | 16 | 61 | 0 | 3 | 3 | 0 | 0 | 1 | 2 | 2.61 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 38 | 0 | 5 | 1 | 4.50 | .299 | 1.26 | 7.2 | 4.1 | 4.5 | 46.0 | 37 | 24 | 23 | 8 | 21 | 23 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 5.70 |
| RP | Perkins, G.Perkins, Glen # >> | 30 | 2013 | L | 48 | 66 | 0 | 3 | 1 | 5.80 | .361 | 1.67 | 11.2 | 4.0 | 7.0 | 49.2 | 61 | 33 | 32 | 6 | 22 | 38 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.45 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 15 | 0 | 3 | 2 | 4.32 | .353 | 1.60 | 7.6 | 6.8 | 9.0 | 25.0 | 21 | 12 | 12 | 3 | 19 | 25 | 0 | 2 | 3 | 0 | 0 | 1 | 1 | 4.96 |