| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 97 | 23 | 23 | 10 | 8 | 3.93 | .284 | 1.17 | 7.9 | 2.6 | 8.8 | 181.0 | 159 | 82 | 79 | 20 | 52 | 177 | 8 | 0 | 0 | 2 | 13 | 4 | 8 | 3.41 |
| SP | Brown, M.Brown, Mordecai † # >> | 32 | 1908 | R | 85 | 21 | 21 | 11 | 8 | 3.01 | .260 | 1.05 | 7.7 | 1.7 | 4.3 | 170.2 | 146 | 59 | 57 | 10 | 33 | 82 | 7 | 0 | 0 | 2 | 14 | 1 | 1 | 3.40 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 71 | 21 | 21 | 5 | 7 | 5.63 | .308 | 1.34 | 9.0 | 3.0 | 5.4 | 128.0 | 128 | 84 | 80 | 21 | 43 | 77 | 0 | 0 | 0 | 0 | 8 | 0 | 3 | 4.94 |
| SP | Harden, R.Harden, Rich # >> | 27 | 2008 | R | 60 | 21 | 21 | 5 | 7 | 7.74 | .381 | 1.78 | 10.2 | 5.9 | 7.3 | 109.1 | 123 | 99 | 94 | 20 | 72 | 88 | 0 | 0 | 0 | 0 | 3 | 7 | 1 | 5.94 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 53 | 0 | 1 | 7 | 4.69 | .349 | 1.58 | 10.9 | 3.4 | 7.9 | 63.1 | 76 | 38 | 33 | 9 | 24 | 55 | 0 | 5 | 4 | 0 | 0 | 2 | 2 | 4.35 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 53 | 0 | 2 | 3 | 4.35 | .281 | 1.14 | 8.6 | 1.7 | 9.0 | 68.1 | 65 | 40 | 33 | 8 | 13 | 68 | 0 | 4 | 1 | 0 | 0 | 2 | 2 | 3.19 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 43 | 0 | 6 | 4 | 4.06 | .317 | 1.35 | 8.5 | 3.7 | 10.4 | 51.0 | 48 | 24 | 23 | 9 | 21 | 59 | 0 | 3 | 4 | 0 | 0 | 2 | 1 | 4.33 |
| SP | Millwood, K.Millwood, Kevin >> | 25 | 1999 | R | 52 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Camnitz, H.Camnitz, Howie >> | 28 | 1909 | R | 56 | 18 | 0 | 1 | 4 | 4.83 | .349 | 1.61 | 10.5 | 4.4 | 4.4 | 31.2 | 36 | 21 | 17 | 6 | 15 | 15 | 0 | 4 | 3 | 0 | 0 | 0 | 0 | 6.00 |