| SP | Kershaw, C.Kershaw, Clayton † >> | 28 | 2016 | L | 99 | 23 | 23 | 12 | 5 | 3.07 | .285 | 1.16 | 8.1 | 2.4 | 7.7 | 175.2 | 158 | 60 | 60 | 16 | 46 | 149 | 5 | 0 | 0 | 2 | 14 | 6 | 3 | 3.38 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 89 | 22 | 22 | 8 | 9 | 5.08 | .336 | 1.51 | 10.0 | 3.6 | 8.2 | 134.2 | 149 | 83 | 76 | 20 | 54 | 122 | 3 | 0 | 0 | 0 | 12 | 1 | 3 | 4.35 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 21 | 21 | 6 | 6 | 4.63 | .301 | 1.28 | 8.2 | 3.4 | 7.9 | 134.0 | 122 | 69 | 69 | 10 | 50 | 118 | 2 | 0 | 0 | 2 | 10 | 1 | 2 | 3.35 |
| SP | Chesbro, J.Chesbro, Jack >> | 30 | 1904 | R | 65 | 21 | 21 | 9 | 8 | 4.82 | .307 | 1.30 | 9.8 | 2.0 | 3.8 | 155.0 | 168 | 89 | 83 | 21 | 34 | 66 | 6 | 0 | 0 | 0 | 9 | 4 | 3 | 4.65 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 67 | 0 | 4 | 0 | 2.39 | .272 | 1.12 | 7.1 | 3.1 | 8.3 | 52.2 | 41 | 14 | 14 | 4 | 18 | 48 | 0 | 4 | 1 | 0 | 0 | 0 | 1 | 3.19 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 46 | 0 | 5 | 9 | 5.98 | .317 | 1.37 | 9.6 | 2.9 | 8.0 | 46.2 | 49 | 33 | 31 | 7 | 15 | 41 | 0 | 4 | 3 | 0 | 0 | 1 | 2 | 4.24 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 25 | 0 | 1 | 0 | 1.80 | .245 | 0.97 | 5.9 | 2.8 | 8.0 | 35.0 | 23 | 8 | 7 | 1 | 11 | 31 | 0 | 3 | 0 | 0 | 0 | 0 | 2 | 2.54 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 23 | 0 | 2 | 1 | 3.16 | .319 | 1.37 | 9.0 | 3.5 | 6.1 | 31.1 | 31 | 11 | 11 | 5 | 12 | 21 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.00 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 10 | 0 | 0 | 2 | 5.55 | .381 | 1.77 | 10.9 | 5.3 | 4.5 | 24.1 | 29 | 16 | 15 | 1 | 14 | 12 | 0 | 3 | 0 | 0 | 0 | 2 | 0 | 4.54 |