| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 32 | 32 | 10 | 10 | 3.68 | .284 | 1.17 | 8.6 | 2.0 | 9.0 | 212.2 | 203 | 97 | 87 | 33 | 46 | 213 | 0 | 0 | 0 | 0 | 20 | 4 | 0 | 3.72 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 31 | 31 | 11 | 14 | 4.41 | .308 | 1.32 | 8.9 | 3.0 | 4.8 | 218.1 | 215 | 112 | 107 | 25 | 73 | 116 | 6 | 0 | 0 | 1 | 17 | 3 | 4 | 4.47 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 30 | 30 | 16 | 11 | 4.09 | .303 | 1.29 | 8.6 | 3.0 | 4.6 | 246.1 | 236 | 115 | 112 | 28 | 81 | 127 | 16 | 0 | 0 | 3 | 13 | 5 | 1 | 4.50 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 29 | 29 | 7 | 12 | 5.48 | .350 | 1.59 | 10.3 | 4.1 | 5.1 | 180.2 | 206 | 110 | 110 | 24 | 82 | 102 | 0 | 0 | 0 | 0 | 10 | 4 | 3 | 5.03 |
| RP | Kimbrel, C.Kimbrel, Craig >> | 24 | 2012 | R | 100 | 78 | 0 | 4 | 4 | 3.70 | .303 | 1.30 | 7.5 | 4.3 | 10.4 | 112.0 | 93 | 48 | 46 | 14 | 53 | 130 | 0 | 9 | 7 | 0 | 0 | 0 | 5 | 3.72 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 76 | 0 | 6 | 6 | 4.78 | .327 | 1.42 | 8.3 | 4.4 | 11.1 | 81.0 | 75 | 43 | 43 | 11 | 40 | 100 | 0 | 6 | 4 | 0 | 0 | 3 | 3 | 3.89 |
| RP | Betancourt, R.Betancourt, Rafael # >> | 32 | 2007 | R | 77 | 46 | 0 | 6 | 3 | 3.91 | .271 | 1.08 | 8.2 | 1.5 | 9.7 | 53.0 | 48 | 23 | 23 | 8 | 9 | 57 | 0 | 3 | 3 | 0 | 0 | 2 | 0 | 3.43 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 30 | 0 | 4 | 3 | 2.76 | .324 | 1.44 | 9.3 | 3.9 | 9.3 | 32.2 | 33 | 15 | 10 | 1 | 14 | 33 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 2.66 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 4 | 1 | 0 | 1 | 6.52 | .310 | 1.34 | 9.0 | 4.0 | 6.0 | 9.2 | 9 | 7 | 7 | 2 | 4 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.89 |