| SP | Johnson, R.Johnson, Randy >> | 42 | 2005 | L | 90 | 12 | 12 | 4 | 6 | 2.89 | .284 | 1.17 | 7.8 | 2.7 | 6.0 | 84.0 | 73 | 28 | 27 | 10 | 25 | 56 | 0 | 0 | 0 | 0 | 8 | 2 | 0 | 4.18 |
| SP | Contreras, J.Contreras, Jose >> | 34 | 2005 | R | 77 | 11 | 11 | 1 | 5 | 5.77 | .358 | 1.63 | 9.3 | 5.3 | 5.9 | 64.0 | 66 | 43 | 41 | 5 | 38 | 42 | 0 | 0 | 0 | 0 | 5 | 3 | 9 | 4.63 |
| SP | Sabathia, C.Sabathia, CC # >> | 25 | 2005 | L | 66 | 12 | 12 | 2 | 6 | 5.85 | .349 | 1.57 | 10.7 | 3.5 | 8.6 | 75.1 | 89 | 51 | 49 | 8 | 29 | 72 | 0 | 0 | 0 | 0 | 4 | 3 | 3 | 3.75 |
| SP | Perez, O.Perez, Odalis >> | 28 | 2005 | L | 52 | 11 | 11 | 3 | 5 | 4.99 | .337 | 1.46 | 9.6 | 3.6 | 5.1 | 57.2 | 61 | 32 | 32 | 12 | 23 | 32 | 0 | 0 | 0 | 0 | 1 | 4 | 1 | 6.04 |
| SP | Maddux, G.Maddux, Greg >> | 39 | 2005 | R | 47 | 11 | 11 | 3 | 7 | 6.06 | .360 | 1.62 | 12.2 | 2.5 | 4.9 | 62.1 | 84 | 43 | 42 | 13 | 17 | 34 | 0 | 0 | 0 | 0 | 3 | 4 | 1 | 5.65 |
| RP | Speier, J.Speier, Justin >> | 32 | 2005 | R | 92 | 32 | 0 | 2 | 1 | 3.04 | .294 | 1.23 | 8.8 | 2.3 | 6.3 | 50.1 | 49 | 17 | 17 | 6 | 13 | 35 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.00 |
| RP | Sanchez, D.Sanchez, Duaner >> | 26 | 2005 | R | 35 | 23 | 0 | 1 | 0 | 4.15 | .345 | 1.58 | 10.8 | 3.6 | 5.4 | 30.1 | 36 | 14 | 14 | 3 | 12 | 18 | 0 | 3 | 2 | 0 | 0 | 0 | 3 | 4.30 |
| RP | Majewski, G.Majewski, Gary >> | 25 | 2005 | R | 23 | 19 | 0 | 1 | 0 | 6.30 | .388 | 1.90 | 8.6 | 8.6 | 7.7 | 20.0 | 19 | 14 | 14 | 4 | 19 | 17 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 6.75 |
| SP | Robertson, N.Robertson, Nate >> | 28 | 2005 | L | 28 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Bedard, E.Bedard, Erik >> | 26 | 2005 | L | 33 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Ohka, T.Ohka, Tomokazu >> | 29 | 2005 | R | 25 | 15 | 0 | 0 | 4 | 8.49 | .386 | 1.89 | 14.1 | 3.1 | 5.5 | 23.1 | 36 | 22 | 22 | 6 | 8 | 14 | 0 | 1 | 2 | 0 | 0 | 0 | 1 | 6.22 |