| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 92 | 22 | 22 | 4 | 14 | 4.06 | .317 | 1.36 | 8.0 | 4.3 | 7.0 | 155.0 | 137 | 77 | 70 | 18 | 74 | 121 | 3 | 0 | 0 | 0 | 12 | 5 | 3 | 4.48 |
| SP | Lackey, J.Lackey, John >> | 27 | 2005 | R | 50 | 21 | 21 | 2 | 12 | 5.93 | .357 | 1.63 | 11.2 | 3.5 | 5.7 | 121.1 | 151 | 85 | 80 | 14 | 47 | 77 | 1 | 0 | 0 | 0 | 7 | 4 | 8 | 4.50 |
| SP | Silva, C.Silva, Carlos >> | 26 | 2005 | R | 49 | 21 | 21 | 6 | 9 | 5.39 | .324 | 1.42 | 11.2 | 1.6 | 4.8 | 127.0 | 158 | 77 | 76 | 30 | 22 | 68 | 0 | 0 | 0 | 0 | 10 | 3 | 0 | 5.59 |
| SP | Washburn, J.Washburn, Jarrod # >> | 31 | 2005 | L | 30 | 21 | 21 | 7 | 8 | 4.86 | .321 | 1.41 | 9.6 | 3.2 | 5.9 | 129.2 | 137 | 79 | 70 | 24 | 46 | 84 | 0 | 0 | 0 | 0 | 9 | 1 | 0 | 5.21 |
| SP | Rogers, K.Rogers, Kenny >> | 41 | 2005 | L | 27 | 19 | 19 | 4 | 13 | 6.87 | .380 | 1.75 | 11.6 | 4.2 | 5.8 | 97.0 | 125 | 83 | 74 | 18 | 45 | 63 | 0 | 0 | 0 | 0 | 5 | 8 | 0 | 5.75 |
| RP | Speier, J.Speier, Justin >> | 32 | 2005 | R | 92 | 61 | 0 | 1 | 6 | 3.35 | .273 | 1.11 | 7.6 | 2.4 | 7.6 | 91.1 | 77 | 35 | 34 | 13 | 24 | 77 | 0 | 4 | 3 | 0 | 0 | 2 | 4 | 4.02 |
| RP | Springer, R.Springer, Russ >> | 37 | 2005 | R | 62 | 53 | 0 | 2 | 8 | 4.30 | .314 | 1.36 | 8.6 | 3.6 | 7.0 | 67.0 | 64 | 35 | 32 | 9 | 27 | 52 | 0 | 6 | 1 | 0 | 0 | 1 | 0 | 4.45 |
| RP | Boyer, B.Boyer, Blaine >> | 24 | 2005 | R | 42 | 42 | 0 | 3 | 2 | 3.29 | .310 | 1.29 | 8.7 | 2.9 | 5.9 | 52.0 | 50 | 20 | 19 | 4 | 17 | 34 | 0 | 0 | 2 | 0 | 0 | 3 | 1 | 3.85 |
| RP | Otsuka, A.Otsuka, Akinori >> | 33 | 2005 | R | 29 | 33 | 0 | 0 | 1 | 8.51 | .439 | 2.35 | 14.4 | 7.2 | 7.5 | 30.2 | 48 | 29 | 29 | 4 | 24 | 25 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 5.47 |
| RP | Burgos, A.Burgos, Ambiorix >> | 21 | 2005 | R | 18 | 25 | 0 | 0 | 1 | 5.65 | .372 | 1.74 | 10.9 | 5.1 | 9.3 | 28.2 | 34 | 19 | 18 | 6 | 16 | 29 | 0 | 1 | 2 | 0 | 0 | 1 | 6 | 5.54 |