| SP | Pettitte, A.Pettitte, Andy # >> | 33 | 2005 | L | 93 | 12 | 12 | 2 | 6 | 5.35 | .320 | 1.38 | 8.8 | 3.8 | 7.1 | 72.1 | 70 | 45 | 43 | 8 | 30 | 57 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 4.19 |
| SP | Wakefield, T.Wakefield, Tim >> | 39 | 2005 | R | 69 | 11 | 11 | 2 | 7 | 5.65 | .360 | 1.65 | 10.8 | 4.1 | 5.7 | 73.1 | 88 | 46 | 46 | 11 | 33 | 46 | 0 | 0 | 0 | 0 | 5 | 3 | 3 | 5.18 |
| SP | Glavine, T.Glavine, Tom >> | 39 | 2005 | L | 14 | 11 | 11 | 3 | 6 | 7.15 | .380 | 1.73 | 12.7 | 3.1 | 5.6 | 56.2 | 79 | 48 | 45 | 6 | 19 | 35 | 0 | 0 | 0 | 0 | 4 | 6 | 2 | 4.48 |
| RP | Duchscherer, J.Duchscherer, Justin >> | 28 | 2005 | R | 89 | 23 | 0 | 3 | 0 | 4.34 | .341 | 1.52 | 9.9 | 3.7 | 9.6 | 29.0 | 32 | 16 | 14 | 4 | 12 | 31 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 4.00 |
| RP | Turnbow, D.Turnbow, Derrick >> | 27 | 2005 | R | 82 | 24 | 0 | 1 | 1 | 3.20 | .283 | 1.14 | 7.9 | 2.5 | 9.4 | 25.1 | 22 | 9 | 9 | 3 | 7 | 26 | 0 | 0 | 1 | 0 | 0 | 1 | 3 | 3.44 |
| RP | Shields, S.Shields, Scot >> | 30 | 2005 | R | 78 | 13 | 0 | 0 | 1 | 2.84 | .309 | 1.34 | 8.3 | 4.5 | 8.3 | 12.2 | 11 | 5 | 4 | 1 | 6 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.75 |
| RP | Heilman, A.Heilman, Aaron >> | 27 | 2005 | R | 71 | 6 | 0 | 1 | 1 | 2.79 | .396 | 1.97 | 13.0 | 6.0 | 9.0 | 9.2 | 13 | 3 | 3 | 0 | 6 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.00 |
| CL | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 88 | 18 | 0 | 0 | 4 | 3.98 | .307 | 1.23 | 9.5 | 1.8 | 7.7 | 20.1 | 21 | 9 | 9 | 2 | 4 | 17 | 0 | 8 | 1 | 0 | 0 | 2 | 0 | 3.50 |